Masfen
Generic Name
Ketotifen Fumarate Ophthalmic Solution 0.025%
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| masfen 0025 eye drop | ৳ 100.30 | N/A |
Description
Overview of the medicine
Masfen 0.025% Eye Drop is an ophthalmic solution containing Ketotifen Fumarate, primarily used to relieve itching of the eyes due to allergic conjunctivitis. It acts as an antihistamine and a mast cell stabilizer.
Uses & Indications
Dosage
Adults
One drop in the affected eye(s) twice daily, every 8 to 12 hours.
Elderly
No special dosage adjustment required.
Renal_impairment
Not applicable for topical ophthalmic use due to minimal systemic absorption.
How to Take
For ophthalmic use only. Tilt head back, pull down the lower eyelid to form a pouch, instill one drop, then close eye gently. Do not touch the dropper tip to any surface.
Mechanism of Action
Ketotifen is a non-competitive H1-receptor antagonist and a mast cell stabilizer. It inhibits histamine release from mast cells and reduces the chemotaxis and activation of eosinophils, thereby alleviating allergic symptoms.
Pharmacokinetics
Onset
Within minutes to hours.
Excretion
Excreted mainly via urine as metabolites.
Half life
Systemic half-life is about 12 hours, but ocular effects are localized.
Absorption
Minimal systemic absorption after ocular administration.
Metabolism
Primarily metabolized in the liver to an inactive metabolite.
Side Effects
Contraindications
- Hypersensitivity to ketotifen or any component of the formulation.
- Contact lenses should be removed before administration and reinserted after at least 10 minutes.
Drug Interactions
Alcohol
May potentiate the effects of alcohol when administered systemically, but negligible for ophthalmic use.
CNS Depressants
May potentiate the effects of CNS depressants when administered systemically, but negligible for ophthalmic use.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Do not freeze.
Overdose
Systemic overdose is unlikely with topical ophthalmic administration. In case of accidental ingestion, seek medical advice.
Pregnancy & Lactation
Category C for pregnancy. Use only if clearly needed. Excretion in human milk is unknown, use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to ketotifen or any component of the formulation.
- Contact lenses should be removed before administration and reinserted after at least 10 minutes.
Drug Interactions
Alcohol
May potentiate the effects of alcohol when administered systemically, but negligible for ophthalmic use.
CNS Depressants
May potentiate the effects of CNS depressants when administered systemically, but negligible for ophthalmic use.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Do not freeze.
Overdose
Systemic overdose is unlikely with topical ophthalmic administration. In case of accidental ingestion, seek medical advice.
Pregnancy & Lactation
Category C for pregnancy. Use only if clearly needed. Excretion in human milk is unknown, use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unopened), 28 days after opening
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
Clinical Trials
Multiple clinical trials have demonstrated the efficacy and safety of ketotifen fumarate for allergic conjunctivitis.
Lab Monitoring
- Not typically required for topical ophthalmic use.
Doctor Notes
- Advise patients about proper administration technique to avoid contamination.
- Educate patients on the duration of use, typically not more than 6-8 weeks without re-evaluation.
Patient Guidelines
- Avoid touching the dropper tip to any surface.
- Remove contact lenses before use and wait 10 minutes before reinserting.
- If using other eye medications, wait at least 5 minutes between applications.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision or mild eye irritation; advise caution when driving or operating machinery if vision is affected.
Lifestyle Advice
- Avoid known allergens that trigger allergic conjunctivitis.
- Maintain good eye hygiene.
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Global Brand Names
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