Maturex
Generic Name
Meturoxib 60 mg tablet
Manufacturer
Alpha Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maturex 60 mg tablet | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Maturex 60 mg tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, and acute pain.
Uses & Indications
Dosage
Adults
Osteoarthritis: 60 mg once daily. Rheumatoid Arthritis: 60 mg once daily. Acute pain: 60 mg once daily, maximum 5 days. Do not exceed 60 mg/day.
Elderly
No specific dosage adjustment usually required, but caution is advised. Start with the lowest effective dose.
Renal_impairment
Mild to moderate renal impairment: No dosage adjustment. Severe renal impairment: Not recommended.
How to Take
Maturex tablet should be taken orally, with or without food. Swallow the tablet whole with a glass of water.
Mechanism of Action
Meturoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, leading to reduced prostaglandin synthesis, which in turn diminishes inflammation, pain, and fever.
Pharmacokinetics
Onset
Within 1-2 hours for analgesic effect.
Excretion
Mainly excreted in urine (approximately 70%) and feces (approximately 30%) as metabolites.
Half life
Approximately 20-24 hours.
Absorption
Well absorbed orally; peak plasma concentrations reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Meturoxib or any component of the tablet
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulceration or gastrointestinal bleeding
- Severe heart failure
- Severe hepatic or renal impairment
- Third trimester of pregnancy
Drug Interactions
Aspirin
Increased risk of GI adverse events. Should not be taken concurrently.
Lithium
Increased plasma lithium levels.
Methotrexate
Increased plasma methotrexate levels.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is symptomatic and supportive. Gastric lavage or activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Pregnancy Category C/D (in third trimester). Avoid use in the third trimester due to potential premature closure of the ductus arteriosus. Use during lactation is not recommended as NSAIDs can pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of Meturoxib in the treatment of various painful and inflammatory conditions. Post-marketing surveillance continues to monitor long-term safety.
Lab Monitoring
- Regular monitoring of blood pressure
- Renal function (e.g., serum creatinine, BUN) periodically
- Liver function tests (e.g., ALT, AST) periodically
- Complete blood count (CBC) in patients on long-term therapy
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration.
- Consider GI and cardiovascular risk factors before prescribing.
- Monitor patients for signs of GI bleeding, cardiovascular events, and renal toxicity, especially in elderly patients or those with pre-existing conditions.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor if you have a history of heart disease, stomach ulcers, or kidney problems.
- Report any unusual bleeding, severe stomach pain, or swelling immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid excessive alcohol consumption while taking this medication.
- Maintain a healthy lifestyle with balanced diet and regular exercise.
- Do not smoke, as smoking increases the risk of GI complications.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.