Maxdol
Generic Name
maxdol-10-mg-tablet
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| maxdol 10 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Maxdol 10 mg Tablet contains Thiocolchicoside, a semi-synthetic derivative of colchicoside. It is used as a muscle relaxant to relieve painful muscle contractures associated with various musculoskeletal conditions.
Uses & Indications
Dosage
Adults
The usual recommended dose is 4 mg twice daily or 8 mg once daily. Maxdol 10 mg tablet should be taken as prescribed by the physician, typically once daily or as 5 mg twice daily depending on clinical assessment.
Elderly
Lower doses may be considered in elderly patients due to potential reduced renal or hepatic function. Close monitoring is advised.
Renal_impairment
Use with caution in patients with renal impairment. Dose adjustment may be necessary based on the degree of impairment.
How to Take
Maxdol tablet should be taken orally, with or without food. It can be taken with a glass of water.
Mechanism of Action
Thiocolchicoside acts as a muscle relaxant, primarily by selectively binding to GABA-A and glycinergic receptors, exhibiting agonistic properties on glycine receptors and antagonistic properties on GABA-A receptors. This central action leads to muscle relaxation and reduction of muscle tone.
Pharmacokinetics
Onset
Onset of action typically occurs within 30-60 minutes.
Excretion
Excreted mainly via urine, with a small portion excreted in feces.
Half life
The elimination half-life of the active metabolite (M2) is approximately 2.5 to 5 hours.
Absorption
Rapidly absorbed after oral administration, with good bioavailability.
Metabolism
Undergoes extensive hepatic metabolism, primarily through glucuronidation, to form active (M2) and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Thiocolchicoside or any component of the tablet
- Flaccid paralysis or muscle hypotonia
- Pregnancy and lactation
- Children under 16 years of age
Drug Interactions
Anticoagulants
Caution advised when co-administered with anticoagulants due to potential for altered prothrombin time.
CNS Depressants
May enhance the sedative effects of other CNS depressants like alcohol, sedatives, or hypnotics.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for Thiocolchicoside overdose.
Pregnancy & Lactation
Maxdol is contraindicated during pregnancy and lactation due to potential genotoxic effects and excretion into breast milk. Women of childbearing potential should use effective contraception during treatment.
Side Effects
Contraindications
- Hypersensitivity to Thiocolchicoside or any component of the tablet
- Flaccid paralysis or muscle hypotonia
- Pregnancy and lactation
- Children under 16 years of age
Drug Interactions
Anticoagulants
Caution advised when co-administered with anticoagulants due to potential for altered prothrombin time.
CNS Depressants
May enhance the sedative effects of other CNS depressants like alcohol, sedatives, or hypnotics.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. There is no specific antidote for Thiocolchicoside overdose.
Pregnancy & Lactation
Maxdol is contraindicated during pregnancy and lactation due to potential genotoxic effects and excretion into breast milk. Women of childbearing potential should use effective contraception during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 36 months from the date of manufacture, when stored under recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Ongoing and completed clinical trials investigate Thiocolchicoside's efficacy and safety in various conditions causing painful muscle spasms, as well as comparative studies with other muscle relaxants. Some trials focus on its genotoxic potential and optimal dosing strategies.
Lab Monitoring
- Liver function tests (LFTs) may be considered for prolonged treatment or in patients with pre-existing liver conditions.
- Renal function monitoring in patients with renal impairment.
Doctor Notes
- Counsel patients about the potential for drowsiness and advise against driving or operating heavy machinery.
- Consider liver function monitoring for patients on prolonged therapy or with underlying liver disease.
- Emphasize the contraindication in pregnancy and lactation.
Patient Guidelines
- Do not exceed the recommended dose.
- Report any unusual side effects to your doctor.
- Avoid alcohol consumption during treatment.
- Store the medicine as directed.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Maxdol may cause drowsiness or dizziness. Patients should be warned not to drive or operate machinery if they experience these effects.
Lifestyle Advice
- Avoid activities requiring mental alertness, such as driving or operating heavy machinery, as this medicine may cause drowsiness.
- Maintain adequate hydration.
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