Mazic
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mazic 10 mg syrup | ৳ 35.00 | N/A |
Description
Overview of the medicine
Mazic 10 mg Syrup contains Omeprazole, a proton pump inhibitor (PPI) used to reduce stomach acid production. It treats conditions like heartburn, acid reflux, ulcers, and erosive esophagitis.
Uses & Indications
Dosage
Adults
Usually 20 mg once daily for 4-8 weeks, or as directed by physician. For Zollinger-Ellison Syndrome, dosage may be higher.
Elderly
No specific dose adjustment is generally needed, but caution advised due to potential for reduced hepatic function.
Renal_impairment
No dose adjustment necessary for patients with impaired renal function.
How to Take
Take orally, preferably in the morning before breakfast. Do not crush or chew if it's a suspension/granule formulation intended for specific administration.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase enzyme system (the proton pump) in gastric parietal cells, thereby blocking the final step of acid secretion.
Pharmacokinetics
Onset
Within 1 hour, maximal effect within 2 hours.
Excretion
Approximately 80% is excreted as metabolites in the urine and about 20% in the feces.
Half life
0.5-1 hour (terminal half-life), but duration of acid suppression is much longer (up to 72 hours) due to irreversible binding.
Absorption
Rapidly absorbed from the gastrointestinal tract, though absorption may be delayed by food. Bioavailability is about 30-40% but increases with repeated dosing.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Omeprazole or any components of the formulation
- Concomitant use with Nelfinavir
Drug Interactions
Diazepam
Increased plasma levels of diazepam.
Warfarin
Increased INR and prothrombin time; monitor closely.
Clopidogrel
Reduced antiplatelet effect of clopidogrel (avoid concomitant use).
Methotrexate
Increased and prolonged elevation of methotrexate serum levels.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited information on overdose. Symptoms may include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Omeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Known hypersensitivity to Omeprazole or any components of the formulation
- Concomitant use with Nelfinavir
Drug Interactions
Diazepam
Increased plasma levels of diazepam.
Warfarin
Increased INR and prothrombin time; monitor closely.
Clopidogrel
Reduced antiplatelet effect of clopidogrel (avoid concomitant use).
Methotrexate
Increased and prolonged elevation of methotrexate serum levels.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited information on overdose. Symptoms may include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Omeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date (unopened). Once opened, use within 30 days.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Omeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Monitor Vitamin B12 levels with prolonged use (over 3 years) due to potential malabsorption.
- Monitor magnesium levels periodically with prolonged use.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary.
- Consider discontinuing PPIs if long-term use is not justified by clinical indications.
- Educate patients on potential long-term risks and lifestyle modifications.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine prematurely, even if you feel better.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid foods and drinks that trigger heartburn (e.g., spicy foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Elevate the head of your bed.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.