MDF-Relief
Generic Name
mdf-(mdf808m)
Manufacturer
Alpha Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Description
Overview of the medicine
mdf-(mdf808m) is a novel analgesic and antipyretic agent indicated for the relief of mild to moderate pain and fever.
Uses & Indications
Dosage
Adults
One 200 mg tablet every 4-6 hours as needed, not exceeding 1200 mg in 24 hours.
Elderly
Lower doses may be required; consult a physician. Not exceeding 800 mg in 24 hours.
Renal_impairment
Use with caution; dose adjustment may be necessary. Not recommended for severe renal impairment.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with water.
Mechanism of Action
Mdf-(mdf808m) is believed to exert its analgesic and antipyretic effects primarily through the inhibition of prostaglandin synthesis by targeting cyclooxygenase (COX) enzymes.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted in urine as metabolites, with a small portion excreted unchanged.
Half life
Approximately 2-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver by oxidation and conjugation.
Side Effects
Contraindications
- Hypersensitivity to mdf-(mdf808m) or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Last trimester of pregnancy
- Severe heart failure
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, drowsiness, and headache. In severe cases, gastrointestinal bleeding, acute renal failure, or respiratory depression may occur. Treatment is primarily symptomatic and supportive; gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Not recommended during the last trimester of pregnancy due to potential fetal harm. Use with caution during early pregnancy and lactation only if clearly needed and benefits outweigh risks. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to mdf-(mdf808m) or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Last trimester of pregnancy
- Severe heart failure
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, drowsiness, and headache. In severe cases, gastrointestinal bleeding, acute renal failure, or respiratory depression may occur. Treatment is primarily symptomatic and supportive; gastric lavage or activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Not recommended during the last trimester of pregnancy due to potential fetal harm. Use with caution during early pregnancy and lactation only if clearly needed and benefits outweigh risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Under Investigation
Patent Status
Pending
Clinical Trials
Ongoing phase III clinical trials for broader indications.
Lab Monitoring
- Periodic monitoring of renal function (creatinine, BUN) for long-term use
- Liver function tests (ALT, AST) if hepatic impairment is suspected
- Complete blood count for signs of bleeding or anemia with prolonged use
Doctor Notes
- Advise patients to report any signs of gastrointestinal bleeding or severe allergic reactions immediately.
- Consider gastroprotective agents for patients at high risk of GI complications.
- Monitor renal function in elderly patients or those with pre-existing renal conditions.
Patient Guidelines
- Do not exceed the recommended dose.
- Take with food or milk to reduce stomach upset.
- Inform your doctor about all other medications you are taking.
- Avoid alcohol while taking this medicine.
- Seek medical attention if symptoms worsen or new symptoms appear.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or drowsiness; exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid activities that exacerbate pain.
- Get enough rest.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.