Mecol
Generic Name
Mecobalamin (Methylcobalamin)
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mecol 500 mcg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Mecobalamin is a vitamin B12 coenzyme, essential for nerve function, red blood cell formation, and DNA synthesis. It is used to treat vitamin B12 deficiency, various types of neuropathies (e.g., peripheral neuropathy, diabetic neuropathy), and megaloblastic anemia.
Uses & Indications
Dosage
Adults
Typically 500 mcg to 1500 mcg daily, administered as a single dose or divided into 2-3 doses. For peripheral neuropathy, 500 mcg orally three times a day is common.
Elderly
No specific dose adjustment is generally required for elderly patients, unless severe renal impairment is present.
Renal_impairment
Use with caution in severe renal impairment. Dose adjustment may be necessary if eGFR is below 30 mL/min/1.73m².
How to Take
Take orally with or without food. Some formulations can be dissolved under the tongue (sublingual) for potentially better absorption.
Mechanism of Action
As an active coenzyme of vitamin B12, Mecobalamin participates in transmethylation reactions, particularly in the synthesis of methionine from homocysteine. It is crucial for myelin sheath formation, nerve regeneration, and maintaining nerve cell health, thereby improving nerve conduction.
Pharmacokinetics
Onset
Clinical effects for chronic conditions like neuropathy may take weeks to months to become noticeable.
Excretion
Primarily excreted via urine (approximately 50-90% unchanged within 48 hours for high doses), with some biliary excretion.
Half life
Plasma half-life is complex due to extensive tissue storage, but terminal elimination half-life can range from a few days to several months.
Absorption
Well absorbed orally; peak plasma concentration typically achieved within 3-4 hours after administration. Bioavailability is about 60-70%.
Metabolism
Mecobalamin is the active form of vitamin B12 and is directly utilized by cells. It is converted to other active coenzymes within the body as needed.
Side Effects
Contraindications
- Hypersensitivity to Mecobalamin or any component of the formulation.
- Patients with Leber's disease (due to risk of optic nerve atrophy).
Drug Interactions
Neomycin
Can impair the absorption of vitamin B12.
Metformin
Prolonged use of metformin can decrease vitamin B12 absorption, especially at higher doses.
Colchicine
May reduce the gastrointestinal absorption of vitamin B12.
Oral Contraceptives
Long-term use may lead to reduced serum B12 levels.
Proton Pump Inhibitors (e.g., Omeprazole)
Can reduce acid production in the stomach, impairing B12 absorption over long-term use.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Mecobalamin has a very low toxicity profile, and overdose is generally not associated with serious adverse effects. Treatment is usually symptomatic and supportive, as no specific antidote exists.
Pregnancy & Lactation
Mecobalamin is generally considered safe during pregnancy and lactation at recommended doses, as vitamin B12 is essential for fetal development and is present in breast milk. However, always consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Mecobalamin or any component of the formulation.
- Patients with Leber's disease (due to risk of optic nerve atrophy).
Drug Interactions
Neomycin
Can impair the absorption of vitamin B12.
Metformin
Prolonged use of metformin can decrease vitamin B12 absorption, especially at higher doses.
Colchicine
May reduce the gastrointestinal absorption of vitamin B12.
Oral Contraceptives
Long-term use may lead to reduced serum B12 levels.
Proton Pump Inhibitors (e.g., Omeprazole)
Can reduce acid production in the stomach, impairing B12 absorption over long-term use.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Mecobalamin has a very low toxicity profile, and overdose is generally not associated with serious adverse effects. Treatment is usually symptomatic and supportive, as no specific antidote exists.
Pregnancy & Lactation
Mecobalamin is generally considered safe during pregnancy and lactation at recommended doses, as vitamin B12 is essential for fetal development and is present in breast milk. However, always consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture, depending on the manufacturer and specific formulation.
Availability
Pharmacies, drugstores
Approval Status
Approved
Patent Status
Off-patent (Generic)
WHO Essential Medicine
YesClinical Trials
Mecobalamin has been extensively studied in numerous clinical trials, demonstrating efficacy in the treatment of vitamin B12 deficiency and various neuropathic conditions, including diabetic neuropathy and peripheral neuropathies.
Lab Monitoring
- Serum B12 levels (before and periodically during treatment for deficiency)
- Complete Blood Count (CBC) to monitor for anemia
- Homocysteine and methylmalonic acid levels (as indicators of B12 functional status)
Doctor Notes
- Educate patients on the importance of addressing the underlying cause of B12 deficiency.
- Monitor patient's clinical response and B12 levels, especially in cases of neurological symptoms.
- Consider B12 supplementation for patients on long-term Metformin or PPIs.
Patient Guidelines
- Take Mecobalamin exactly as prescribed by your doctor.
- Do not exceed the recommended dose without consulting your physician.
- Inform your doctor about all other medications, supplements, and herbal products you are currently taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Mecobalamin is not known to cause drowsiness or impair driving ability. Therefore, no specific driving precautions are usually necessary.
Lifestyle Advice
- Maintain a balanced diet rich in vitamin B12 (e.g., meat, fish, dairy, eggs).
- Avoid excessive alcohol consumption, as it can interfere with B12 absorption.
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