Mecozol
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals PLC
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mecozol 400 mg tablet | ৳ 1.00 | N/A |
| mecozol 200 mg suspension | ৳ 25.00 | N/A |
Description
Overview of the medicine
Mecozol (Omeprazole) is a proton pump inhibitor that reduces the amount of acid produced in the stomach. It is used to treat conditions such as stomach ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
For GERD: 20-40 mg once daily for 4-8 weeks. For duodenal ulcer: 20 mg once daily for 2-4 weeks. For gastric ulcer: 20 mg once daily for 4-8 weeks. For H. pylori eradication: 20 mg twice daily in combination with antibiotics.
Elderly
No specific dose adjustment is required, but caution is advised in elderly patients with hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take orally, usually once daily in the morning, before a meal. Swallow the capsule whole with water; do not chew or crush.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase enzyme (the proton pump) in the gastric parietal cells, thereby suppressing gastric acid secretion.
Pharmacokinetics
Onset
Onset of acid suppression occurs within 1 hour, with maximum effect within 2 hours.
Excretion
Approximately 80% of metabolites are excreted in the urine and the remainder in the feces.
Half life
Plasma half-life is short, about 0.5 to 1 hour, but the duration of acid suppression is much longer due to irreversible binding to the proton pump.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 0.5 to 3.5 hours. Bioavailability is approximately 30-40%.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any other proton pump inhibitors.
- Coadministration with nelfinavir.
Drug Interactions
Diazepam
Omeprazole can prolong the elimination of diazepam.
Warfarin
May increase INR and prothrombin time, requiring monitoring.
Clopidogrel
Concomitant use may reduce the antiplatelet effect of clopidogrel.
Methotrexate
Concomitant use may increase and prolong serum levels of methotrexate.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit justifies potential risk to the fetus. Lactation: Omeprazole is excreted in human milk. Caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture. Refer to the specific packaging for exact expiry date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Patent expired, generic available
WHO Essential Medicine
YesClinical Trials
Omeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various acid-related disorders. Post-marketing surveillance also continues to monitor its effects.
Lab Monitoring
- Serum magnesium levels should be monitored periodically in patients expected to be on long-term treatment.
- Liver function tests in patients with hepatic impairment.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary to achieve the desired therapeutic effect.
- Consider periodic monitoring of magnesium levels in patients on long-term therapy, especially if concomitantly taking diuretics.
- Be aware of potential drug interactions, particularly with clopidogrel and methotrexate.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not crush or chew the capsules; swallow them whole.
- Inform your doctor about all medications you are taking, including over-the-counter drugs and herbal supplements.
- Do not stop taking the medicine suddenly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Mecozol is generally not expected to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness or visual disturbances, avoid driving or operating machinery until you feel well.
Lifestyle Advice
- Avoid foods and drinks that trigger your acid reflux symptoms, such as fatty foods, spicy foods, caffeine, and alcohol.
- Elevate the head of your bed to help reduce nighttime acid reflux.
- Maintain a healthy weight.
- Eat smaller, more frequent meals.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.