Medrolin
Generic Name
Methylprednisolone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| medrolin 50 mg tablet | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Medrolin contains Methylprednisolone, a synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive properties. It is used to treat a wide range of conditions, including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.
Uses & Indications
Dosage
Adults
Dosage varies widely based on condition. Initial dose often 4-48 mg/day orally, once daily or in divided doses. Tapering is crucial for long-term use.
Elderly
No specific dose adjustments needed, but monitor for side effects due to increased susceptibility.
Renal_impairment
No specific dose adjustments required. Use with caution in severe cases due to fluid retention risk.
How to Take
Oral tablets should be taken with food or milk to minimize gastrointestinal upset. Injectable forms are administered intravenously or intramuscularly by a healthcare professional.
Mechanism of Action
Methylprednisolone binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus. This complex modulates gene expression, leading to the synthesis of anti-inflammatory proteins and inhibition of pro-inflammatory mediators. It suppresses immune cell activity and reduces capillary permeability, thereby decreasing inflammation and immune responses.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within hours.
Excretion
Excreted mainly through urine as metabolites.
Half life
Biological half-life is 18-36 hours; plasma half-life is 2-3 hours.
Absorption
Rapidly and well absorbed after oral administration. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver by CYP3A4 enzymes to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
Drug Interactions
Warfarin
Altered anticoagulant effects; monitor INR.
Diuretics (e.g., furosemide)
Increased risk of hypokalemia.
Non-steroidal anti-inflammatory drugs (NSAIDs)
Increased risk of gastrointestinal bleeding/ulceration.
CYP3A4 inducers (e.g., rifampicin, phenobarbital)
May decrease methylprednisolone levels.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
May increase methylprednisolone levels.
Storage
Store at controlled room temperature (20-25°C), protected from light and moisture. Do not freeze.
Overdose
Acute overdose is rare. Chronic overdose symptoms include Cushingoid features (moon face, buffalo hump), muscle weakness, and fluid retention. Treatment is symptomatic and supportive; gradual withdrawal is key for chronic overdose.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Methylprednisolone is excreted in breast milk; advise caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, as indicated on the packaging.
Availability
Pharmacies, hospitals
Approval Status
Globally approved for decades
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Methylprednisolone has been extensively studied in numerous clinical trials for its efficacy in various inflammatory and autoimmune conditions.
Lab Monitoring
- Blood glucose (especially in diabetics)
- Electrolytes (potassium)
- Blood pressure
- Bone density (with long-term use)
- Ophthalmologic exams (for cataracts/glaucoma)
Doctor Notes
- Always consider the risk-benefit ratio, especially for long-term therapy.
- Educate patients on the importance of not discontinuing the drug abruptly and the signs of adrenal insufficiency.
- Monitor for signs of infection, blood glucose levels, blood pressure, and bone density regularly.
Patient Guidelines
- Do not stop taking Medrolin abruptly, especially after long-term use, as it may lead to withdrawal symptoms. Follow your doctor's instructions for tapering the dose.
- Report any unusual side effects or worsening of your condition to your doctor immediately.
- Avoid contact with people who have infections (e.g., chickenpox, measles) if you are taking this medicine, as your immune system may be weakened.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Medrolin generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or vision changes, avoid these activities.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health.
- Exercise regularly, but avoid strenuous activities if you have bone density issues.
- Monitor blood sugar levels if you are diabetic.
- Limit salt intake to help manage fluid retention and blood pressure.
- Regularly wash hands and practice good hygiene to reduce infection risk.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.