Mefalgin
Generic Name
Mefenamic Acid + Paracetamol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mefalgin 250 mg tablet | ৳ 1.80 | N/A |
| mefalgin 500 mg tablet | ৳ 4.00 | N/A |
| mefalgin 50 mg suspension | ৳ 30.00 | N/A |
Description
Overview of the medicine
Mefalgin is a combination medication containing Mefenamic Acid, a non-steroidal anti-inflammatory drug (NSAID), and Paracetamol, an analgesic and antipyretic. It is used to relieve pain, reduce inflammation, and lower fever.
Uses & Indications
Dosage
Adults
Typically 1 tablet (Mefenamic Acid 250 mg + Paracetamol 325 mg) 2-3 times daily, or as directed by physician. Maximum daily dose for Mefenamic Acid should not exceed 1000 mg and Paracetamol 4000 mg.
Elderly
Lower doses may be required due to increased risk of side effects and impaired renal function. Consult physician.
Renal_impairment
Use with caution; dose adjustment may be necessary. Not recommended for severe renal impairment.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Mefenamic Acid inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. Paracetamol primarily inhibits prostaglandin synthesis in the central nervous system, producing analgesic and antipyretic effects.
Pharmacokinetics
Onset
Analgesic effect typically within 30-60 minutes.
Excretion
Primarily excreted in urine as metabolites and unconjugated drug. A small amount is excreted in feces.
Half life
Mefenamic Acid: Approximately 2-4 hours. Paracetamol: Approximately 1.25-3 hours.
Absorption
Both Mefenamic Acid and Paracetamol are well absorbed from the gastrointestinal tract. Peak plasma concentrations for Mefenamic Acid are reached within 2-4 hours, and for Paracetamol, within 0.5-2 hours.
Metabolism
Mefenamic Acid is metabolized in the liver by cytochrome P450 enzymes (primarily CYP2C9). Paracetamol is extensively metabolized in the liver, mainly by conjugation with glucuronide and sulfate, and a small amount by CYP2E1 to a toxic metabolite, NAPQI.
Side Effects
Contraindications
- Hypersensitivity to Mefenamic Acid, Paracetamol, or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
Alcohol
Increased risk of liver damage with Paracetamol, increased GI side effects with Mefenamic Acid.
Cholestyramine
Reduced absorption of Paracetamol.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Lithium, Methotrexate
Increased plasma levels and toxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Diuretics, ACE inhibitors, Angiotensin II receptor blockers
Reduced antihypertensive effect; increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, drowsiness. Severe overdose, especially with Paracetamol, can lead to liver damage. Gastric lavage, activated charcoal, and specific antidotes like N-acetylcysteine for Paracetamol overdose should be administered under medical supervision.
Pregnancy & Lactation
Avoid during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution in other trimesters if benefits outweigh risks. Mefenamic Acid and Paracetamol pass into breast milk; use with caution in lactating mothers, generally considered safe for short-term use at recommended doses.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA, Bangladesh
Patent Status
Generic available (Patent expired)
Clinical Trials
Clinical trials have established the efficacy and safety of Mefenamic Acid and Paracetamol combination for pain and fever relief. Ongoing research may explore new indications or formulations.
Lab Monitoring
- Liver function tests (LFTs) for prolonged use
- Renal function tests (RFTs) for prolonged use or in patients with risk factors
- Complete blood count (CBC) for prolonged use
Doctor Notes
- Caution in patients with a history of GI disorders, cardiovascular disease, or renal/hepatic impairment.
- Monitor for signs of GI bleeding and cardiovascular events.
- Educate patients on proper dosage and potential side effects.
Patient Guidelines
- Do not exceed the recommended dose.
- Take with food to minimize stomach upset.
- Report any unusual bleeding, persistent stomach pain, or dark stools to your doctor.
- Avoid concomitant use with other NSAIDs or Paracetamol-containing products.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or drowsiness in some individuals. If affected, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain adequate hydration.
- Limit alcohol intake.
- Report any new or worsening symptoms to your healthcare provider.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.