Meformin
Generic Name
Metformin Hydrochloride 500 mg Tablet
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| meformin 500 mg tablet | ৳ 2.00 | ৳ 20.00 |
Description
Overview of the medicine
Metformin 500 mg tablet is an oral medication used to treat type 2 diabetes. It helps to lower blood glucose levels by improving the body's response to insulin and decreasing glucose production in the liver. It is often used in combination with diet and exercise.
Uses & Indications
Dosage
Adults
Initial dose 500 mg orally twice daily with meals or 850 mg orally once daily with meals. Titrate gradually to a maximum of 2000-2550 mg daily.
Elderly
Initial dose 500 mg once daily. Dose titration should be gradual and careful due to potential decreased renal function.
Renal_impairment
Not recommended if eGFR < 30 mL/min/1.73 m². Dose adjustment required for eGFR 30-45 mL/min/1.73 m².
How to Take
Take orally with meals to reduce gastrointestinal side effects. Swallow the tablet whole; do not crush or chew.
Mechanism of Action
Metformin primarily decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. It does not stimulate insulin secretion, thus typically does not cause hypoglycemia.
Pharmacokinetics
Onset
Within a few days, full effect in 1-2 weeks.
Excretion
Excreted unchanged in the urine.
Half life
Approximately 4-9 hours.
Absorption
Oral bioavailability is 50-60%. Food delays absorption and decreases Cmax.
Metabolism
Not metabolized in the liver.
Side Effects
Contraindications
- •Severe renal impairment (eGFR < 30 mL/min/1.73 m²)
- •Metabolic acidosis (including diabetic ketoacidosis)
- •Hypersensitivity to Metformin
- •Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma
Drug Interactions
Cimetidine
May increase metformin concentration, increasing risk of lactic acidosis.
Corticosteroids
May increase blood glucose levels, requiring metformin dose adjustment.
Iodinated Contrast Agents
Temporarily discontinue metformin at or before the procedure and restart 48 hours later if renal function is stable.
Diuretics (thiazide, loop)
May worsen glycemic control.
Storage
Store at room temperature (20-25°C), away from moisture and light. Keep out of reach of children.
Overdose
Overdose may lead to lactic acidosis. Treatment involves supportive measures, correction of acidosis, and hemodialysis for severe cases.
Pregnancy & Lactation
Consult a doctor. Metformin is generally considered safer than other oral antidiabetics during pregnancy but insulin is often preferred. Small amounts pass into breast milk; generally considered compatible with breastfeeding with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA (US) and DGDA (Bangladesh)
Patent Status
Generic available (patent expired for original formulation)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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