Megafen
Generic Name
Ibuprofen + Paracetamol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| megafen 50 mg tablet | ৳ 0.81 | ৳ 8.10 |
| megafen 75 mg injection | ৳ 10.18 | N/A |
Description
Overview of the medicine
Megafen is a combination medicine containing Ibuprofen and Paracetamol, used to relieve mild to moderate pain, inflammation, and fever. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain, while Paracetamol is an analgesic and antipyretic that helps reduce pain and fever.
Uses & Indications
Dosage
Adults
Adults: 1 tablet 2 to 3 times daily, preferably after food. Do not exceed 3 tablets in 24 hours.
Elderly
Elderly: Use the lowest effective dose for the shortest duration. Monitor for adverse effects, especially gastrointestinal.
Renal_impairment
Renal impairment: Use with caution. Dosage reduction may be necessary depending on the degree of impairment. Not recommended in severe renal failure.
How to Take
Take orally, preferably with or after food, to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Ibuprofen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever. Paracetamol's mechanism is not fully understood but is thought to involve central inhibition of prostaglandin synthesis and effects on serotonergic descending pathways, leading to analgesic and antipyretic effects.
Pharmacokinetics
Onset
Onset of pain relief usually within 30-60 minutes.
Excretion
Both are primarily excreted via the kidneys as inactive metabolites. A small amount of Ibuprofen is excreted unchanged.
Half life
Ibuprofen: 1.8-3.5 hours; Paracetamol: 1-4 hours.
Absorption
Both Ibuprofen and Paracetamol are rapidly and well absorbed orally. Ibuprofen peak plasma concentration is reached in 1-2 hours; Paracetamol in 0.5-2 hours.
Metabolism
Both are primarily metabolized in the liver. Ibuprofen by oxidation and conjugation; Paracetamol mainly by conjugation with glucuronic acid and sulfate.
Side Effects
Contraindications
- Hypersensitivity to Ibuprofen, Paracetamol, or any component of the formulation
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure, renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Alcohol
Increased risk of hepatotoxicity with Paracetamol and gastrointestinal irritation with Ibuprofen.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced efficacy of diuretics and ACE inhibitors, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of Ibuprofen overdose may include nausea, vomiting, abdominal pain, drowsiness, and central nervous system depression. Paracetamol overdose can cause severe liver damage. Management typically involves activated charcoal if recent ingestion, supportive care, and N-acetylcysteine for paracetamol overdose.
Pregnancy & Lactation
Ibuprofen is contraindicated in the third trimester of pregnancy due to risks to the fetus. Both drugs should be used during pregnancy and lactation only if the potential benefit outweighs the potential risk. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Ibuprofen, Paracetamol, or any component of the formulation
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure, renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Alcohol
Increased risk of hepatotoxicity with Paracetamol and gastrointestinal irritation with Ibuprofen.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced efficacy of diuretics and ACE inhibitors, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of Ibuprofen overdose may include nausea, vomiting, abdominal pain, drowsiness, and central nervous system depression. Paracetamol overdose can cause severe liver damage. Management typically involves activated charcoal if recent ingestion, supportive care, and N-acetylcysteine for paracetamol overdose.
Pregnancy & Lactation
Ibuprofen is contraindicated in the third trimester of pregnancy due to risks to the fetus. Both drugs should be used during pregnancy and lactation only if the potential benefit outweighs the potential risk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
The efficacy and safety of Ibuprofen and Paracetamol as individual agents are well-established through extensive clinical trials. Their combination in fixed-dose formulations is widely used for synergistic pain relief.
Lab Monitoring
- For long-term use, periodically monitor renal function tests (e.g., creatinine, BUN).
- Liver function tests (e.g., ALT, AST) may be considered, especially in patients with risk factors for liver dysfunction.
- Complete blood count (CBC) to monitor for anemia or other blood dyscrasias.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with patient treatment goals.
- Exercise caution in patients with a history of GI disorders, cardiovascular disease, hypertension, or renal/hepatic impairment.
- Advise patients to report any signs of GI bleeding, unusual bruising, or allergic reactions promptly.
Patient Guidelines
- Do not exceed the recommended dose to avoid serious side effects.
- Take the medicine with food or milk to reduce stomach upset.
- Inform your doctor about all other medications you are taking, especially blood thinners or other pain relievers.
- Consult your doctor if pain or fever persists for more than a few days.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking this medication.
- Maintain adequate hydration, especially if you experience gastrointestinal side effects.
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