Melafresh
Generic Name
Melafresh-001-4-Cream
Manufacturer
Global Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| melafresh 001 4 cream | ৳ 190.00 | N/A |
Description
Overview of the medicine
Melafresh-001-4-Cream is a topical cream designed to reduce hyperpigmentation, dark spots, and uneven skin tone. It contains a blend of active ingredients that work synergistically to brighten the skin and promote a more even complexion.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected areas of the skin once or twice daily, or as directed by a physician. Gently massage until absorbed.
Elderly
No specific dosage adjustment required for elderly, use as adult dosage.
Renal_impairment
No specific dosage adjustment required as systemic absorption is minimal.
How to Take
For external use only. Apply on clean, dry skin. Avoid contact with eyes, mouth, and other mucous membranes.
Mechanism of Action
Alpha Arbutin inhibits tyrosinase activity, an enzyme crucial for melanin production. Kojic Acid also acts as a tyrosinase inhibitor, chelating copper in the enzyme's active site, thereby reducing melanin synthesis. Together, they block multiple steps in the melanogenesis pathway, leading to skin lightening.
Pharmacokinetics
Onset
Visible improvement typically within 4-8 weeks of regular use.
Excretion
Primarily through epidermal turnover; minimal systemic excretion.
Half life
Not well-defined for topical cosmetic ingredients, as systemic levels are negligible.
Absorption
Minimal systemic absorption through topical application. Primarily acts locally on the epidermis.
Metabolism
Local enzymatic degradation in the skin; minimal systemic metabolism.
Side Effects
Contraindications
- •Hypersensitivity to any component of the cream
- •Broken or irritated skin
- •Use in children under 12 years of age (unless directed by physician)
Drug Interactions
Other depigmenting agents
May increase skin irritation or sensitivity if used concurrently.
Abrasive soaps or cleansers
May increase skin irritation.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Over-application may lead to skin irritation, redness, or peeling. If ingested, seek medical attention.
Pregnancy & Lactation
Consult a physician before use during pregnancy or lactation. While systemic absorption is minimal, data on safety in these populations may be limited.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, Skincare Stores
Approval Status
Approved by DGDA
Patent Status
No active patent for this specific formulation
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Global Brand Names
International brand names for this medicine
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