Melanxit
Generic Name
Melatonin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| melanxit 05 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Melatonin is a hormone produced naturally by the pineal gland. It helps regulate sleep-wake cycles (circadian rhythm). Melanxit 5 mg Tablet is used to treat insomnia and jet lag.
Uses & Indications
Dosage
Adults
Typically 2-5 mg taken 30-60 minutes before bedtime. Dosage may vary based on individual response and condition.
Elderly
Start with a lower dose (e.g., 1-2 mg) due to increased sensitivity and slower metabolism.
Renal_impairment
No specific dosage adjustment guidelines; use with caution. Consult a physician.
How to Take
Take orally with water, 30-60 minutes before bedtime. Do not crush or chew the tablet if it's an extended-release formulation (though 5mg is typically immediate release).
Mechanism of Action
Melatonin primarily acts on MT1 and MT2 receptors in the suprachiasmatic nucleus (SCN) of the hypothalamus. MT1 receptor activation promotes sleep onset, while MT2 receptor activation shifts the timing of the circadian rhythm. It mimics the body's natural melatonin production to induce sleep.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Renal (approx. 90% as metabolites, 10% as unchanged drug)
Half life
0.5-5 hours (highly variable)
Absorption
Rapidly absorbed from the GI tract; peak plasma concentrations achieved within 15-60 minutes.
Metabolism
Extensively metabolized in the liver, primarily by CYP1A2 and CYP1A1, to 6-hydroxymelatonin and its sulfate and glucuronide conjugates.
Side Effects
Contraindications
- Hypersensitivity to melatonin or any component of the formulation
- Autoimmune diseases (theoretical concern)
- Pregnancy and lactation (insufficient data)
Drug Interactions
Fluvoxamine
Significantly increases melatonin levels.
Anticoagulants
May increase bleeding risk.
CNS Depressants
May enhance sedative effects.
Immunosuppressants
May interfere with their action.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, disorientation, and prolonged sleep. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy or breastfeeding due to insufficient data on safety. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to melatonin or any component of the formulation
- Autoimmune diseases (theoretical concern)
- Pregnancy and lactation (insufficient data)
Drug Interactions
Fluvoxamine
Significantly increases melatonin levels.
Anticoagulants
May increase bleeding risk.
CNS Depressants
May enhance sedative effects.
Immunosuppressants
May interfere with their action.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, disorientation, and prolonged sleep. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy or breastfeeding due to insufficient data on safety. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, online pharmacies
Approval Status
Approved
Patent Status
Generic available, original patent expired
Clinical Trials
Numerous clinical trials have supported the efficacy and safety of melatonin for various sleep disorders, particularly for primary insomnia and jet lag.
Lab Monitoring
- Generally no routine lab monitoring required.
Doctor Notes
- Advise patients on sleep hygiene practices.
- Consider underlying causes of insomnia before prescribing.
- Monitor for daytime drowsiness and adjust dose if necessary.
Patient Guidelines
- Take before bedtime as directed.
- Avoid driving or operating heavy machinery after taking this medicine.
- Do not consume alcohol while on this medication.
- Consult your doctor if symptoms persist or worsen.
Missed Dose Advice
If you miss a dose and it's still before bedtime, take it as soon as you remember. If it's already past your usual bedtime, skip the missed dose and resume your regular schedule. Do not take a double dose.
Driving Precautions
May cause drowsiness or dizziness. Do not drive or operate heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a consistent sleep schedule.
- Ensure a dark, quiet, and cool sleep environment.
- Avoid large meals, caffeine, and alcohol before bedtime.
- Incorporate regular exercise during the day.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.