Melphin
Generic Name
Meloxicam
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| melphin 125 mg tablet | ৳ 1.66 | ৳ 16.58 |
| melphin 50 mg suspension | ৳ 16.10 | N/A |
Description
Overview of the medicine
Melphin contains Meloxicam, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness from arthritis.
Uses & Indications
Dosage
Adults
Osteoarthritis: 7.5 mg once daily, max 15 mg/day. Rheumatoid arthritis/Ankylosing spondylitis: 15 mg once daily.
Elderly
Generally 7.5 mg once daily, adjust based on renal function.
Renal_impairment
Severe renal impairment (CrCl < 30 mL/min) not recommended. For mild to moderate, generally 7.5 mg once daily.
How to Take
Taken orally, once daily, with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Meloxicam inhibits prostaglandin synthesis by primarily inhibiting cyclooxygenase-2 (COX-2), leading to reduced inflammation and pain.
Pharmacokinetics
Onset
Within 30-60 minutes
Excretion
Excreted in urine and feces in roughly equal proportions as metabolites.
Half life
Approximately 15-20 hours
Absorption
Well absorbed from the gastrointestinal tract; absolute bioavailability is 89%.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9 and to a lesser extent CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Meloxicam or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after aspirin or other NSAIDs
- Peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
- Active gastrointestinal bleeding or ulceration
- Severe hepatic impairment
- Severe renal impairment not on dialysis
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased lithium plasma levels.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors/ARBs
Increased risk of renal impairment.
Diuretics (Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (Warfarin)
Increased risk of bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, GI bleeding. Severe cases may lead to hypertension, acute renal failure, respiratory depression, and coma. Management is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid in late pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use with caution during lactation; small amounts may pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Expired
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in inflammatory conditions. Post-marketing surveillance continues.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver function tests (LFTs)
- Renal function tests (Creatinine, BUN)
- Blood pressure monitoring
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for signs of GI bleeding and cardiovascular events.
- Assess renal function periodically, especially in elderly or patients with pre-existing renal impairment.
Patient Guidelines
- Take with food to minimize stomach upset.
- Do not exceed the recommended dose.
- Report any signs of stomach bleeding (e.g., black, tarry stools).
- Avoid alcohol while on this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that Meloxicam therapy does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Maintain a healthy weight to reduce joint stress.
- Engage in regular, low-impact exercise.
- Consult with a physiotherapist for joint care.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.