Melpred
Generic Name
methylprednisolone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| melpred 2 mg tablet | ৳ 3.00 | ৳ 45.00 |
| melpred 4 mg tablet | ৳ 6.00 | ৳ 90.00 |
| melpred 8 mg tablet | ৳ 11.00 | ৳ 165.00 |
| melpred 16 mg tablet | ৳ 22.00 | ৳ 220.00 |
Description
Overview of the medicine
Methylprednisolone is a synthetic corticosteroid used for its potent anti-inflammatory and immunosuppressive effects. It treats various conditions including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders.
Uses & Indications
Dosage
Adults
Initial dose 4-48 mg daily, depending on condition, tapered gradually
Elderly
Use with caution, lower doses may be required
Renal_impairment
No specific dose adjustment needed, but monitor closely
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Do not stop abruptly.
Mechanism of Action
Methylprednisolone works by binding to intracellular glucocorticoid receptors, forming a complex that translocates into the nucleus and modulates gene expression. This leads to inhibition of inflammatory mediators and immune cell function.
Pharmacokinetics
Onset
Oral onset within hours
Excretion
Excreted primarily in urine as inactive metabolites
Half life
Plasma half-life 2-3 hours, biological half-life 18-36 hours
Absorption
Well absorbed orally
Metabolism
Extensively metabolized in the liver via CYP3A4
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulcers and bleeding.
CYP3A4 inhibitors (e.g., ketoconazole)
May increase methylprednisolone levels and effects.
Storage
Store below 30°C, in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Management involves supportive and symptomatic treatment. Long-term overdose leads to Cushingoid features.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. Methylprednisolone is excreted in breast milk; advise caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities worldwide
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established its efficacy for various inflammatory and autoimmune diseases. Ongoing research explores new therapeutic applications.
Lab Monitoring
- Blood glucose
- Electrolytes
- Bone mineral density (long-term use)
- Ophthalmic exams (long-term use)
Doctor Notes
- Emphasize the importance of gradual tapering to avoid adrenal crisis.
- Monitor patients for signs of infection and metabolic disturbances.
- Educate patients on potential side effects and when to seek medical attention.
Patient Guidelines
- Take exactly as prescribed and do not stop suddenly without consulting your doctor.
- Report any unusual side effects or worsening conditions.
- Avoid exposure to infections, especially chickenpox or measles.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Methylprednisolone generally does not impair ability to drive or operate machinery, but monitor for dizziness or vision changes.
Lifestyle Advice
- Maintain a balanced diet, potentially with calcium and vitamin D supplements to prevent bone loss.
- Avoid alcohol and smoking as they can exacerbate gastrointestinal side effects.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.