Menorest
Generic Name
Estradiol
Manufacturer
Typical manufacturer for Estradiol products (e.g., Novartis, other generic companies)
Country
Various, depending on manufacturer (e.g., Switzerland, India, Bangladesh)
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| menorest 25 mg tablet | ৳ 20.07 | ৳ 561.96 |
Description
Overview of the medicine
Menorest 25 mg Tablet contains Estradiol, an estrogen hormone, used primarily for hormone replacement therapy (HRT) to relieve symptoms of menopause and prevent postmenopausal osteoporosis. It mimics the natural estrogen levels in the body.
Uses & Indications
Dosage
Adults
The usual starting dose for Estradiol tablets is 0.5 mg to 2 mg orally once daily. A 25 mg dose is highly atypical for an oral Estradiol tablet and generally not recommended. Dosage should be individualized by physician based on patient's response and tolerability.
Elderly
No specific dose adjustment is generally required, but caution is advised due to potential increased sensitivity and comorbidities. Lowest effective dose should be used.
Renal_impairment
No specific dose adjustment is necessary, but careful monitoring is recommended as estrogen metabolism may be altered.
How to Take
Take the tablet orally once daily, with or without food. It is important to take it at the same time each day. Follow your doctor's instructions precisely.
Mechanism of Action
Estradiol binds to and activates estrogen receptors (ER-alpha and ER-beta) in target tissues, leading to gene expression modulation. This action helps alleviate menopausal symptoms and maintain bone density.
Pharmacokinetics
Onset
Symptom relief typically begins within a few weeks of consistent use.
Excretion
Excreted mainly in the urine as glucuronide and sulfate conjugates; some fecal excretion.
Half life
Approximately 1-2 hours (for parent Estradiol); active metabolites have longer half-lives.
Absorption
Well absorbed from the gastrointestinal tract; however, extensive first-pass metabolism occurs, leading to low bioavailability. Absorption rate can vary.
Metabolism
Primarily hepatic, via CYP450 enzymes (CYP3A4) to estrone and estriol, followed by conjugation.
Side Effects
Contraindications
- •Undiagnosed abnormal genital bleeding.
- •Breast cancer or estrogen-dependent neoplasia (known or suspected).
- •Deep vein thrombosis (DVT), pulmonary embolism (PE), or a history of these conditions.
- •Active or recent arterial thromboembolic disease (e.g., stroke, myocardial infarction).
- •Liver dysfunction or disease.
- •Known hypersensitivity to Estradiol or any components of the tablet.
- •Pregnancy.
Drug Interactions
Anticoagulants
Estrogens may alter the effects of oral anticoagulants, requiring monitoring of INR.
Thyroid Hormones
Estrogens can increase thyroid-binding globulin, requiring increased thyroid hormone dose in patients on thyroid replacement therapy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin)
May increase estrogen plasma concentrations, potentially leading to increased side effects.
CYP3A4 Inducers (e.g., Rifampicin, Carbamazepine, Phenytoin, St. John's Wort)
May decrease estrogen plasma concentrations, potentially reducing therapeutic effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include nausea, vomiting, breast tenderness, abdominal pain, drowsiness, and withdrawal bleeding. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Menorest 25 mg Tablet is contraindicated during pregnancy. It should not be used during lactation as estrogens are excreted in breast milk and may reduce milk production. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA) for various Estradiol formulations.
Patent Status
Generics available, patent expired for Estradiol.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in