Mepogest
Generic Name
Medroxyprogesterone Acetate 10 mg tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mepogest 10 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Medroxyprogesterone Acetate 10 mg is a synthetic progestin used for various gynecological conditions and hormone replacement therapy. It mimics the effects of the natural hormone progesterone in the body.
Uses & Indications
Dosage
Adults
For secondary amenorrhea, 5-10 mg daily for 5-10 days. For abnormal uterine bleeding, 5-10 mg daily for 5-10 days, starting on day 16 or 21 of the menstrual cycle. For HRT, 2.5-10 mg daily depending on the regimen. Always follow doctor's advice.
Elderly
No specific dose adjustment, but use with caution.
Renal_impairment
No specific dose adjustment generally needed, but caution advised.
How to Take
Take orally with or without food, as directed by your doctor. Swallow the tablet whole with water.
Mechanism of Action
Medroxyprogesterone Acetate acts on progesterone receptors in the uterus, pituitary gland, and hypothalamus. It inhibits gonadotropin secretion, preventing follicular maturation and ovulation. It also causes endometrial changes, making it unsuitable for implantation.
Pharmacokinetics
Onset
Effects typically seen within a few hours for acute effects (e.g., bleeding control).
Excretion
Mainly via urine and feces as glucuronide conjugates.
Half life
12-17 hours
Absorption
Well absorbed orally. Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Primarily hepatic (liver) by hydroxylation and conjugation.
Side Effects
Contraindications
- •Undiagnosed vaginal bleeding
- •Known or suspected pregnancy
- •Known or suspected hormone-dependent malignancies (e.g., breast cancer)
- •Thromboembolic disorders (current or history)
- •Severe liver disease
Drug Interactions
Grapefruit Juice
May increase MPA levels.
Aminoglutethimide
May decrease plasma concentrations of MPA.
Rifampicin, Carbamazepine, Phenytoin
Enzyme inducers that can accelerate MPA metabolism, reducing efficacy.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms may include nausea, vomiting, and vaginal bleeding. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Contraindicated during pregnancy. May cause fetal abnormalities. Lactation: Small amounts may pass into breast milk. Use with caution, consult doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
More Medicines
Explore other medicines you might be interested in
