Mepred
Generic Name
Methylprednisolone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mepred 8 mg tablet | ৳ 10.50 | ৳ 105.00 |
Description
Overview of the medicine
Methylprednisolone is a synthetic corticosteroid used to treat a variety of conditions, including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, and breathing disorders. It works by reducing inflammation and suppressing the immune system.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the condition being treated and patient response. Initial adult dosage typically ranges from 4 mg to 48 mg per day, given as a single dose or in divided doses. For acute severe conditions, higher doses may be required.
Elderly
No specific dose adjustment is generally required, but caution should be exercised due to increased susceptibility to side effects, especially osteoporosis and gastrointestinal bleeding.
Renal_impairment
No specific dose adjustment is usually required in patients with renal impairment, as methylprednisolone is primarily metabolized by the liver.
How to Take
Take the tablet orally, preferably with food or milk, to minimize gastrointestinal upset. It is usually taken once daily or in divided doses as directed by a physician. Do not crush, chew, or break the tablet unless specifically instructed.
Mechanism of Action
Methylprednisolone acts by binding to specific glucocorticoid receptors in the cytoplasm, forming a complex that translocates to the nucleus. This complex then modulates gene expression, leading to the synthesis of anti-inflammatory proteins and the inhibition of pro-inflammatory mediators. It also suppresses various components of the immune system.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within a few hours, but full therapeutic effects may take days.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Plasma half-life is approximately 2.5-3.5 hours; biological half-life is 18-36 hours.
Absorption
Readily absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
Drug Interactions
Anticoagulants (e.g., warfarin)
Methylprednisolone may enhance or diminish the effects of anticoagulants; close monitoring of INR is recommended.
Diuretics (e.g., thiazides, loop diuretics)
May enhance potassium depletion.
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Concurrent use may increase the risk of gastrointestinal ulceration and bleeding.
CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
Can increase methylprednisolone plasma concentrations, potentially leading to increased side effects.
Antidiabetic agents (e.g., insulin, oral hypoglycemics)
Corticosteroids can increase blood glucose levels, requiring dose adjustments of antidiabetic medications.
CYP3A4 inducers (e.g., rifampin, phenobarbital, phenytoin)
Can decrease methylprednisolone plasma concentrations, reducing its effectiveness.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose with methylprednisolone is rare and usually does not lead to life-threatening situations. Chronic overdose can lead to signs of hypercorticism (e.g., Cushing's syndrome). Treatment is symptomatic and supportive; no specific antidote is available. Gradual withdrawal of the drug may be necessary.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Methylprednisolone is excreted into breast milk and may cause adverse effects in nursing infants; a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (Generic)
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Methylprednisolone has undergone extensive clinical trials supporting its efficacy and safety across various indications. Ongoing research continues to explore new applications and refine treatment protocols for corticosteroids.
Lab Monitoring
- Blood glucose levels (especially in diabetic or predisposed patients)
- Electrolyte levels (e.g., potassium, sodium)
- Blood pressure monitoring
- Bone density scans (for long-term use)
- Intraocular pressure (for long-term use)
- Growth monitoring in pediatric patients
Doctor Notes
- Always consider the lowest effective dose for the shortest possible duration to minimize adverse effects.
- Patients on long-term therapy require regular monitoring for bone density, blood glucose, electrolytes, and ocular pressure.
- Educate patients on the importance of not discontinuing the drug abruptly and the signs of adrenal insufficiency.
- Exercise caution in patients with active infections, peptic ulcer disease, heart failure, or uncontrolled diabetes.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor; do not alter the dose or stop abruptly without consulting your doctor.
- Take with food or milk to reduce stomach upset.
- Report any unusual side effects or worsening of your condition to your doctor immediately.
- Carry an identification card indicating you are on corticosteroid therapy, especially if you need emergency medical attention.
- Avoid close contact with people who are sick or have infections, as your immune system may be suppressed.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Methylprednisolone generally does not impair the ability to drive or operate machinery. However, if you experience side effects such as dizziness, blurred vision, or mood changes, you should avoid these activities until you are sure you can perform them safely.
Lifestyle Advice
- Maintain a balanced diet, potentially with reduced sodium and increased potassium intake. Engage in weight-bearing exercises to help maintain bone density (if appropriate). Avoid smoking and excessive alcohol consumption.
- Monitor for signs of infection and practice good hygiene.
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Global Brand Names
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