Merostat
Generic Name
meropenem
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| merostat 1 gm injection | ৳ 1,275.00 | N/A |
| merostat 500 mg injection | ৳ 675.00 | N/A |
Description
Overview of the medicine
Meropenem is a broad-spectrum carbapenem antibiotic used to treat a wide variety of bacterial infections, including intra-abdominal infections, meningitis, and pneumonia.
Uses & Indications
Dosage
Adults
500 mg to 1 g IV every 8 hours, depending on infection severity and type.
Elderly
Dose adjustment based on renal function, similar to adults.
Renal_impairment
Dose reduction required based on creatinine clearance.
How to Take
Intravenous infusion over 15-30 minutes, or intravenous bolus injection over 3-5 minutes for doses up to 1 g.
Mechanism of Action
Meropenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid, within minutes of administration.
Excretion
Mainly via urine (70% unchanged drug).
Half life
Approximately 1 hour in adults.
Absorption
Rapidly absorbed after intravenous administration.
Metabolism
Primarily hydrolyzed by dehydropeptidase-I, but meropenem is relatively stable to this enzyme. Minor metabolism.
Side Effects
Contraindications
- Hypersensitivity to meropenem or other carbapenems
- Severe hypersensitivity (e.g., anaphylactic reaction) to any other beta-lactam antibacterial agent
Drug Interactions
Probenecid
Increases meropenem plasma concentration and prolongs its half-life.
Valproic Acid
Reduced serum valproic acid levels, potentially leading to loss of seizure control.
Oral Anticoagulants
Increased anticoagulant effect when co-administered with antibiotics, including carbapenems.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
In cases of overdose, symptomatic and supportive treatment should be given. Hemodialysis can be used to remove meropenem from the body.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution.
Side Effects
Contraindications
- Hypersensitivity to meropenem or other carbapenems
- Severe hypersensitivity (e.g., anaphylactic reaction) to any other beta-lactam antibacterial agent
Drug Interactions
Probenecid
Increases meropenem plasma concentration and prolongs its half-life.
Valproic Acid
Reduced serum valproic acid levels, potentially leading to loss of seizure control.
Oral Anticoagulants
Increased anticoagulant effect when co-administered with antibiotics, including carbapenems.
Storage
Store below 30°C. Protect from light. Do not freeze.
Overdose
In cases of overdose, symptomatic and supportive treatment should be given. Hemodialysis can be used to remove meropenem from the body.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when stored as recommended.
Availability
Hospitals, pharmacies
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established meropenem's efficacy and safety in various infections.
Lab Monitoring
- Renal function tests (creatinine clearance)
- Liver function tests
- Complete blood count (CBC)
Doctor Notes
- Consider susceptibility testing before initiation.
- Adjust dose in renal impairment.
- Monitor for seizures, especially in patients with CNS disorders.
Patient Guidelines
- Report any signs of allergic reaction immediately.
- Complete the full course of treatment, even if symptoms improve.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, it should be given as soon as possible, unless it is almost time for the next dose. Do not double the dose.
Driving Precautions
Meropenem may cause dizziness or seizures. Patients should be advised to exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Follow doctor's instructions strictly.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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