Mesagut
Generic Name
Mesalamine
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mesagut 400 mg tablet | ৳ 7.60 | ৳ 76.00 |
Description
Overview of the medicine
Mesalamine is an anti-inflammatory drug used to treat and prevent flare-ups of ulcerative colitis and Crohn's disease.
Uses & Indications
Dosage
Adults
For Ulcerative Colitis: 800 mg three times daily (2.4 g/day) for 6 weeks. Maintenance: 1.2-2.4 g/day in divided doses.
Elderly
Use with caution; consider reduced dosage due to potential for decreased renal function.
Renal_impairment
Use with caution. Monitor renal function. Avoid if creatinine clearance <30 mL/min.
How to Take
Oral. Swallow whole with water, do not crush or chew. Can be taken with or without food.
Mechanism of Action
Mesalamine works locally in the bowel to reduce inflammation by inhibiting cyclooxygenase and lipoxygenase pathways, reducing prostaglandin and leukotriene synthesis, and scavenging free radicals.
Pharmacokinetics
Onset
Clinical improvement often seen within 3-21 days, full effect may take longer.
Excretion
Mainly excreted in feces as unchanged drug and metabolite; a smaller portion excreted renally.
Half life
Systemic half-life is short (0.5-1.5 hours for parent drug, 5-10 hours for N-acetyl-5-ASA metabolite).
Absorption
Varies depending on formulation; oral forms are generally poorly absorbed systemically, aiming for local action in the colon.
Metabolism
Undergoes N-acetylation in the liver and colonic mucosa to form N-acetyl-5-aminosalicylic acid (N-Ac-5-ASA), which is inactive.
Side Effects
Contraindications
- •Hypersensitivity to mesalamine, salicylates, or any component of the formulation
- •Severe renal or hepatic impairment
Drug Interactions
NSAIDs
May increase risk of renal toxicity; avoid concomitant use if possible.
Azathioprine/Mercaptopurine
Increased risk of myelosuppression.
Lactulose or other osmotic laxatives
May interfere with mesalamine release from some formulations.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms include nausea, vomiting, abdominal pain, headache, vertigo. Management is supportive, including gastric lavage and activated charcoal if recent ingestion.
Pregnancy & Lactation
Use during pregnancy only if clearly needed after careful risk/benefit assessment. Excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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