Mesartin Plus
Generic Name
Olmesartan Medoxomil + Amlodipine Besylate
Manufacturer
Reputable Pharmaceutical Company
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mesartin plus 5 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Mesartin Plus 5 mg Tablet is a combination medicine used to treat high blood pressure (hypertension). It contains Olmesartan, an angiotensin receptor blocker (ARB), and Amlodipine, a calcium channel blocker (CCB). This combination effectively lowers blood pressure by relaxing blood vessels and making it easier for the heart to pump blood.
Uses & Indications
Dosage
Adults
Usually 1 tablet once daily, preferably at the same time each day.
Elderly
No initial dosage adjustment is generally required, but caution is advised in patients with impaired renal or hepatic function.
Renal_impairment
No initial dosage adjustment is usually required for mild to moderate renal impairment. For severe renal impairment, lower doses or alternative treatments may be considered.
How to Take
Mesartin Plus 5 mg Tablet should be taken orally with or without food. It is recommended to take it at approximately the same time each day.
Mechanism of Action
Olmesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues. Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. This reduces peripheral vascular resistance and lowers blood pressure.
Pharmacokinetics
Onset
Olmesartan: 2 hours. Amlodipine: 6-12 hours.
Excretion
Olmesartan: Primarily via bile (50-65%) and urine (30-35%). Amlodipine: Excreted as inactive metabolites (60%) and unchanged drug (10%) in urine.
Half life
Olmesartan: 13 hours. Amlodipine: 30-50 hours.
Absorption
Olmesartan: Bioavailability is approximately 26%. Amlodipine: Bioavailability is 64-90%.
Metabolism
Olmesartan: Not significantly metabolized by cytochrome P450 system. Amlodipine: Extensively metabolized by the liver to inactive metabolites via CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Olmesartan, Amlodipine, or any component of the formulation
- Pregnancy (second and third trimesters)
- Severe hepatic impairment
- Bilateral renal artery stenosis
- Shock (including cardiogenic shock)
- Severe hypotension
- Obstruction of the outflow tract of the left ventricle (e.g., severe aortic stenosis)
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal function deterioration.
Potassium-sparing diuretics/potassium supplements
May increase serum potassium levels.
CYP3A4 inducers (e.g., rifampicin, St. John's wort)
May decrease amlodipine exposure.
CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)
May increase amlodipine exposure.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include profound hypotension and possibly reflex tachycardia. Management involves symptomatic and supportive treatment. If recent ingestion, gastric lavage may be considered. Intravenous fluids and vasopressors may be needed for hypotension.
Pregnancy & Lactation
Pregnancy: Contraindicated in the second and third trimesters due to fetal toxicity (black box warning). Discontinue if pregnancy is detected. Lactation: Not recommended. It is unknown if olmesartan is excreted in human milk. Amlodipine is excreted in human milk, but the effect on the breastfed infant is unknown.
Side Effects
Contraindications
- Hypersensitivity to Olmesartan, Amlodipine, or any component of the formulation
- Pregnancy (second and third trimesters)
- Severe hepatic impairment
- Bilateral renal artery stenosis
- Shock (including cardiogenic shock)
- Severe hypotension
- Obstruction of the outflow tract of the left ventricle (e.g., severe aortic stenosis)
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal function deterioration.
Potassium-sparing diuretics/potassium supplements
May increase serum potassium levels.
CYP3A4 inducers (e.g., rifampicin, St. John's wort)
May decrease amlodipine exposure.
CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)
May increase amlodipine exposure.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include profound hypotension and possibly reflex tachycardia. Management involves symptomatic and supportive treatment. If recent ingestion, gastric lavage may be considered. Intravenous fluids and vasopressors may be needed for hypotension.
Pregnancy & Lactation
Pregnancy: Contraindicated in the second and third trimesters due to fetal toxicity (black box warning). Discontinue if pregnancy is detected. Lactation: Not recommended. It is unknown if olmesartan is excreted in human milk. Amlodipine is excreted in human milk, but the effect on the breastfed infant is unknown.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Generics available (Patent expired for main components)
Clinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of the Olmesartan/Amlodipine combination in reducing blood pressure and improving cardiovascular outcomes in patients with hypertension. Studies such as those published in the Journal of Clinical Hypertension and American Journal of Cardiovascular Drugs have confirmed its effectiveness.
Lab Monitoring
- Serum electrolytes (especially potassium)
- Renal function (BUN, creatinine)
- Liver function tests (LFTs)
- Blood pressure monitoring
Doctor Notes
- Monitor blood pressure regularly.
- Assess renal function and serum electrolytes periodically.
- Educate patients on symptoms of hypotension and angioedema.
- Caution in patients with severe aortic stenosis or hypertrophic obstructive cardiomyopathy.
Patient Guidelines
- Take daily as prescribed, even if you feel well.
- Do not stop the medication suddenly without consulting your doctor.
- Inform your doctor about all other medications and supplements you are taking.
- Avoid grapefruit juice while on this medication.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Mesartin Plus 5 mg Tablet may cause dizziness or fatigue. If you experience these symptoms, avoid driving or operating heavy machinery until you know how the medicine affects you.
Lifestyle Advice
- Adopt a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity.
- Maintain a healthy weight.
- Limit alcohol consumption.
- Quit smoking.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.