Metco
Generic Name
Metoprolol Succinate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| metco 400 mg tablet | ৳ 1.70 | ৳ 17.00 |
| metco 500 mg injection | ৳ 85.50 | N/A |
| metco 200 mg suspension | ৳ 35.00 | N/A |
Description
Overview of the medicine
Metco is a beta-blocker medication used to treat high blood pressure, angina, and heart failure. It works by reducing heart rate and relaxing blood vessels.
Uses & Indications
Dosage
Adults
Typically 25-200 mg once daily, depending on the condition being treated.
Elderly
Similar to adult dosage, but consider starting with a lower dose.
Renal_impairment
Generally no dosage adjustment is required for renal impairment.
How to Take
Take orally once daily, preferably at the same time each day, with or without food. Swallow the tablet whole; do not crush or chew.
Mechanism of Action
Metoprolol Succinate selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, cardiac output, and blood pressure.
Pharmacokinetics
Onset
Onset of action for extended-release is gradual, typically taking several hours for full effect.
Excretion
Primarily excreted via the kidneys, with a small amount of unchanged drug.
Half life
Plasma half-life is 3 to 7 hours.
Absorption
Slowly and almost completely absorbed from the gastrointestinal tract after oral administration.
Metabolism
Primarily metabolized in the liver, mainly by CYP2D6 enzyme.
Side Effects
Contraindications
- Severe bradycardia
- Second or third-degree heart block
- Cardiogenic shock
- Decompensated heart failure
Drug Interactions
MAOIs
Concomitant use may result in significant hypertension.
NSAIDs
May reduce the antihypertensive effect of metoprolol.
Digoxin
May enhance bradycardic effects.
Verapamil/Diltiazem
May increase the risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, bronchospasm, and cardiac failure. Management involves supportive care, including atropine for bradycardia and intravenous fluids for hypotension.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a physician.
Side Effects
Contraindications
- Severe bradycardia
- Second or third-degree heart block
- Cardiogenic shock
- Decompensated heart failure
Drug Interactions
MAOIs
Concomitant use may result in significant hypertension.
NSAIDs
May reduce the antihypertensive effect of metoprolol.
Digoxin
May enhance bradycardic effects.
Verapamil/Diltiazem
May increase the risk of bradycardia and hypotension.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, bronchospasm, and cardiac failure. Management involves supportive care, including atropine for bradycardia and intravenous fluids for hypotension.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus or infant. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of metoprolol in managing hypertension, angina, and heart failure.
Lab Monitoring
- Blood pressure
- Heart rate
- ECG
- Renal function (periodically)
Doctor Notes
- Advise patients about the dangers of abrupt withdrawal.
- Use with caution in patients with asthma or COPD.
Patient Guidelines
- Take the medication exactly as prescribed by your doctor.
- Do not stop taking Metco abruptly without consulting your doctor.
- Regularly monitor your blood pressure at home if advised.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Metco may cause dizziness or fatigue. Exercise caution when driving or operating machinery until you know how the medication affects you.
Lifestyle Advice
- Adopt a healthy diet low in salt and saturated fats.
- Engage in regular physical activity.
- Quit smoking and limit alcohol consumption.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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