Metglip-Plus
Generic Name
Metformin Hydrochloride + Teneligliptin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| metglip plus 25 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Metglip-Plus-25-mg-tablet is a combination medicine containing Metformin and Teneligliptin, used to improve blood sugar control in adults with type 2 diabetes mellitus.
Uses & Indications
Dosage
Adults
Usually one tablet once or twice daily, depending on the Metformin strength and physician's discretion. Typically, Metformin 500mg/1000mg + Teneligliptin 25mg once or twice daily with meals.
Elderly
Dosage should be individualized based on renal function. Close monitoring of renal function is recommended.
Renal_impairment
Not recommended for severe renal impairment (eGFR < 30 mL/min/1.73m²). Dose adjustment may be necessary for moderate impairment.
How to Take
Take orally with a meal to reduce gastrointestinal side effects, typically once or twice daily as prescribed. Swallow the tablet whole, do not crush or chew.
Mechanism of Action
Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity. Teneligliptin is a DPP-4 inhibitor that increases levels of active incretin hormones (GLP-1 and GIP), which enhance glucose-dependent insulin secretion and suppress glucagon secretion.
Pharmacokinetics
Onset
Within hours for glucose lowering.
Excretion
Metformin: Primarily excreted unchanged in urine. Teneligliptin: Excreted via both renal and hepatic routes.
Half life
Metformin: 4-9 hours. Teneligliptin: Approximately 24 hours.
Absorption
Metformin: Absolute bioavailability 50-60%. Teneligliptin: Rapidly absorbed, peak plasma concentration within 1-2 hours.
Metabolism
Metformin: Not metabolized. Teneligliptin: Primarily metabolized by CYP3A4 and FMO3.
Side Effects
Contraindications
- Hypersensitivity to Metformin, Teneligliptin, or any excipients
- Severe renal impairment (eGFR < 30 mL/min/1.73m²)
- Metabolic acidosis, including diabetic ketoacidosis
- Acute or chronic metabolic acidosis
- Liver impairment
- Severe congestive heart failure
Drug Interactions
Alcohol
Increases the risk of lactic acidosis with Metformin.
Iodinated contrast agents
Temporarily discontinue Metformin before or at the time of the procedure and for 48 hours afterward.
Diuretics (especially loop diuretics)
May increase the risk of lactic acidosis.
Corticosteroids, Sympathomimetics, Thiazides
May reduce glycemic control.
Cationic drugs (e.g., Amiloride, Digoxin, Morphin, Procainamide)
May increase Metformin concentration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms: Lactic acidosis, hypoglycemia, gastrointestinal disturbances. Management: Discontinue drug, symptomatic and supportive treatment. Hemodialysis for Metformin removal.
Pregnancy & Lactation
Pregnancy: Limited data. Use only if benefits outweigh risks. Insulin is generally preferred. Lactation: Metformin is excreted into breast milk. Unknown for Teneligliptin. Use with caution. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Metformin, Teneligliptin, or any excipients
- Severe renal impairment (eGFR < 30 mL/min/1.73m²)
- Metabolic acidosis, including diabetic ketoacidosis
- Acute or chronic metabolic acidosis
- Liver impairment
- Severe congestive heart failure
Drug Interactions
Alcohol
Increases the risk of lactic acidosis with Metformin.
Iodinated contrast agents
Temporarily discontinue Metformin before or at the time of the procedure and for 48 hours afterward.
Diuretics (especially loop diuretics)
May increase the risk of lactic acidosis.
Corticosteroids, Sympathomimetics, Thiazides
May reduce glycemic control.
Cationic drugs (e.g., Amiloride, Digoxin, Morphin, Procainamide)
May increase Metformin concentration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms: Lactic acidosis, hypoglycemia, gastrointestinal disturbances. Management: Discontinue drug, symptomatic and supportive treatment. Hemodialysis for Metformin removal.
Pregnancy & Lactation
Pregnancy: Limited data. Use only if benefits outweigh risks. Insulin is generally preferred. Lactation: Metformin is excreted into breast milk. Unknown for Teneligliptin. Use with caution. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic versions available
Clinical Trials
Ongoing and completed clinical trials for Metformin and Teneligliptin for type 2 diabetes management.
Lab Monitoring
- Fasting and postprandial blood glucose levels
- HbA1c (every 3-6 months)
- Renal function (eGFR) before initiation and at least annually
- Vitamin B12 levels (for long-term Metformin use)
- Liver function tests (periodically)
Doctor Notes
- Emphasize lifestyle modifications (diet, exercise) alongside medication.
- Regular monitoring of renal function, HbA1c, and blood glucose is crucial.
- Educate patients on symptoms of hypoglycemia and lactic acidosis.
Patient Guidelines
- Take the medicine as prescribed by your doctor.
- Follow a healthy diet and regular exercise routine.
- Monitor your blood sugar levels regularly.
- Be aware of the symptoms of hypoglycemia and how to treat it.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally does not affect driving ability unless hypoglycemia occurs. Patients should be aware of hypoglycemia symptoms before driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in fiber and low in refined sugars.
- Engage in regular physical activity for at least 30 minutes most days of the week.
- Manage stress and get adequate sleep.
- Avoid excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.