Methasol-N
Generic Name
Dexamethasone + Neomycin Sulfate Eye Drop
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| methasol n 01 05 eye drop | ৳ 35.11 | N/A |
Description
Overview of the medicine
Methasol-N eye drop is a combination medication containing a corticosteroid (Dexamethasone) to reduce inflammation and an aminoglycoside antibiotic (Neomycin Sulfate) to treat bacterial infections in the eye. It is used to manage ocular inflammatory conditions where bacterial infection is present or there is a risk of bacterial infection.
Uses & Indications
Dosage
Adults
Instill 1-2 drops into the affected eye(s) 3-4 times daily, or as directed by a physician. The frequency may be reduced as the condition improves.
Elderly
No specific dosage adjustment is generally required for elderly patients.
Renal_impairment
No specific dosage adjustment is required for topical ophthalmic use, as systemic absorption is minimal.
How to Take
For ophthalmic use only. Wash hands before use. Tilt head back, pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac. Do not let the dropper tip touch the eye or any other surface. Close the eye gently for a few moments. If more than one ophthalmic product is being used, administer them at least 5 minutes apart.
Mechanism of Action
Dexamethasone acts by inhibiting the release of inflammatory mediators, thereby reducing swelling, redness, and itching. Neomycin Sulfate is a broad-spectrum aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to bacterial cell death.
Pharmacokinetics
Onset
Onset of anti-inflammatory and antibacterial action is relatively rapid, typically within hours of administration.
Excretion
Systemic excretion is negligible. Primarily local action and degradation in ocular tissues.
Half life
Systemic half-life is not clinically significant due to minimal absorption. Local half-life in ocular tissues varies.
Absorption
Minimal systemic absorption occurs after topical ophthalmic administration. Local absorption into ocular tissues provides therapeutic concentrations.
Metabolism
Minimal systemic metabolism due to very low absorption. Dexamethasone absorbed systemically is metabolized by the liver.
Side Effects
Contraindications
- Hypersensitivity to Dexamethasone, Neomycin Sulfate, or any component of the formulation
- Acute purulent untreated bacterial infections of the eye
- Acute viral diseases of the cornea and conjunctiva (e.g., Herpes Simplex Keratitis)
- Fungal diseases of ocular structures
- Mycobacterial infections of the eye
- Vaccinia, Varicella, and most other viral diseases of the cornea and conjunctiva
- Glaucoma (relative contraindication for prolonged use)
Drug Interactions
Other topical ophthalmic medications
If multiple eye medications are used, administer them at least 5 minutes apart to avoid washout effects. Systemic interactions are unlikely due to minimal absorption.
Storage
Store at room temperature (below 25°C), protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose with topical ophthalmic application is unlikely. If excessive drops are applied, rinse the eye with lukewarm water. Systemic effects from ocular overdose are rare.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Dexamethasone and Neomycin can be excreted in human milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Dexamethasone, Neomycin Sulfate, or any component of the formulation
- Acute purulent untreated bacterial infections of the eye
- Acute viral diseases of the cornea and conjunctiva (e.g., Herpes Simplex Keratitis)
- Fungal diseases of ocular structures
- Mycobacterial infections of the eye
- Vaccinia, Varicella, and most other viral diseases of the cornea and conjunctiva
- Glaucoma (relative contraindication for prolonged use)
Drug Interactions
Other topical ophthalmic medications
If multiple eye medications are used, administer them at least 5 minutes apart to avoid washout effects. Systemic interactions are unlikely due to minimal absorption.
Storage
Store at room temperature (below 25°C), protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Overdose with topical ophthalmic application is unlikely. If excessive drops are applied, rinse the eye with lukewarm water. Systemic effects from ocular overdose are rare.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Dexamethasone and Neomycin can be excreted in human milk; caution should be exercised when administered to a nursing mother. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unopened: Usually 24-36 months. After opening: Discard 28 days after opening.
Availability
Available in pharmacies and clinics
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent (generic available)
Clinical Trials
Efficacy and safety of Dexamethasone-Neomycin ophthalmic preparations have been established through various clinical trials for bacterial ocular infections and inflammation.
Lab Monitoring
- For prolonged use (more than 10 days), regular monitoring of intraocular pressure (IOP) is recommended.
- Periodic ophthalmic examination to check for cataracts or corneal changes.
Doctor Notes
- Prescribe for the shortest possible duration to minimize steroid-related side effects.
- Monitor intraocular pressure if used for more than 10 days.
- Educate patients on proper administration technique and signs of potential complications.
Patient Guidelines
- Do not touch the dropper tip to any surface to avoid contamination.
- Remove contact lenses before applying the eye drop and wait at least 15 minutes before reinserting them.
- Shake the bottle gently before use.
- Do not use for longer than prescribed by your doctor to avoid potential side effects and resistance.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
This medicine may cause temporary blurred vision. Do not drive or operate machinery until your vision is clear.
Lifestyle Advice
- Maintain good ocular hygiene to prevent reinfection.
- Avoid rubbing the eyes, especially when an infection is present.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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