Metherspan
Generic Name
Metherspan-200 mcg injection
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| metherspan 200 mcg injection | ৳ 3.00 | N/A |
Description
Overview of the medicine
Metherspan 200 mcg Injection is a synthetic corticosteroid used for its potent anti-inflammatory and immunosuppressive effects in various conditions.
Uses & Indications
Dosage
Adults
Typical starting dose is 200 mcg administered intramuscularly or intravenously, adjusted based on response and severity. Doses may range from 100 mcg to 1000 mcg daily depending on the condition.
Elderly
Use with caution; lower doses may be required due to decreased renal or hepatic function.
Renal_impairment
No specific dose adjustment typically required, but monitor for fluid retention and electrolyte imbalance.
How to Take
Administer intramuscularly into a large muscle mass (e.g., gluteal muscle) or intravenously as a slow injection or infusion, as directed by a healthcare professional.
Mechanism of Action
Metherspan acts by binding to glucocorticoid receptors, modulating gene expression to inhibit the synthesis of inflammatory mediators and suppress immune responses.
Pharmacokinetics
Onset
Within minutes to hours depending on route and condition.
Excretion
Excreted primarily in the urine as inactive metabolites.
Half life
Biological half-life is approximately 18-36 hours; plasma half-life is 2-4 hours.
Absorption
Rapidly absorbed after intramuscular or intravenous administration. Peak plasma concentrations are achieved within 30-60 minutes.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes, mainly CYP3A4.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to metherspan or any component of the formulation
- Administration of live or live-attenuated vaccines during therapy (unless absolutely necessary)
Drug Interactions
Diuretics
Increased risk of hypokalemia.
Anticoagulants
May alter anticoagulant effects; careful monitoring of INR/PT is recommended.
CYP3A4 Inducers (e.g., rifampicin, phenytoin)
May increase the metabolism of metherspan, leading to decreased plasma concentrations and reduced efficacy.
CYP3A4 Inhibitors (e.g., ketoconazole, clarithromycin)
May decrease the metabolism of metherspan, leading to increased plasma concentrations and potential for adverse effects.
Storage
Store below 30°C. Do not freeze. Protect from light and moisture.
Overdose
Acute overdose is rare. Symptoms may include fluid retention, hypertension, and electrolyte imbalance. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Small amounts may pass into breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to metherspan or any component of the formulation
- Administration of live or live-attenuated vaccines during therapy (unless absolutely necessary)
Drug Interactions
Diuretics
Increased risk of hypokalemia.
Anticoagulants
May alter anticoagulant effects; careful monitoring of INR/PT is recommended.
CYP3A4 Inducers (e.g., rifampicin, phenytoin)
May increase the metabolism of metherspan, leading to decreased plasma concentrations and reduced efficacy.
CYP3A4 Inhibitors (e.g., ketoconazole, clarithromycin)
May decrease the metabolism of metherspan, leading to increased plasma concentrations and potential for adverse effects.
Storage
Store below 30°C. Do not freeze. Protect from light and moisture.
Overdose
Acute overdose is rare. Symptoms may include fluid retention, hypertension, and electrolyte imbalance. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Small amounts may pass into breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Hospitals, retail pharmacies, and specialized clinics worldwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic (Patent expired/not applicable)
Clinical Trials
Extensive clinical trials have demonstrated efficacy and safety in various inflammatory and immune-mediated conditions.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels (especially potassium)
- Blood pressure
- Bone mineral density (for long-term use)
Doctor Notes
- Gradual tapering of dose is crucial to prevent adrenal insufficiency.
- Consider bone protection and gastroprotection for long-term therapy.
- Educate patients about signs of infection and need for immediate reporting.
Patient Guidelines
- Do not stop the medication suddenly without consulting your doctor.
- Report any signs of infection immediately.
- Monitor blood sugar levels if you are diabetic.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Caution is advised as some side effects like dizziness or vision changes may impair driving ability.
Lifestyle Advice
- Maintain a balanced diet to prevent weight gain.
- Engage in regular, moderate exercise to support bone health.
- Avoid exposure to people with contagious diseases.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Metherspan Brand
Other medicines available under the same brand name
