Methilon
Generic Name
Methylprednisolone
Manufacturer
Various (e.g., Square Pharmaceuticals Ltd. in Bangladesh)
Country
Global (manufactured in many countries)
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| methilon 8 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Methylprednisolone is a synthetic glucocorticoid (a type of corticosteroid) used for its potent anti-inflammatory and immunosuppressive properties. It's used to treat a wide range of conditions, including allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.
Uses & Indications
Dosage
Adults
Dosage varies widely based on the condition being treated and patient response. Typically ranges from 4 mg to 48 mg per day, given as a single dose or in divided doses. For 8 mg tablet, common starting doses might be 8 mg once or twice daily, tapering as needed.
Elderly
No specific dose adjustment for elderly patients is usually required, but use with caution due to increased susceptibility to side effects, especially osteoporosis and fluid retention. Start with the lowest effective dose.
Renal_impairment
No dose adjustment is generally necessary for patients with renal impairment, as methylprednisolone is primarily metabolized by the liver. However, monitor for fluid retention.
How to Take
Take orally, usually with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet unless specifically instructed by a doctor.
Mechanism of Action
Methylprednisolone works by binding to glucocorticoid receptors, which leads to changes in gene expression. This results in the inhibition of various inflammatory mediators (e.g., prostaglandins, leukotrienes) and suppression of immune responses. It stabilizes lysosomal membranes, reduces capillary permeability, and inhibits migration of leukocytes to sites of inflammation.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within hours of administration.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Plasma half-life is approximately 2-3 hours; biological half-life is 18-36 hours.
Absorption
Well absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Primarily metabolized in the liver by the cytochrome P450 3A4 (CYP3A4) enzyme system. It is hydroxylated to inactive metabolites.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to methylprednisolone or any component of the formulation
- Administration of live or live-attenuated vaccines in patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
NSAIDs (e.g., Ibuprofen)
Increased risk of gastrointestinal bleeding and ulceration.
Diuretics (e.g., Furosemide)
Increased risk of hypokalemia.
Antidiabetics (e.g., Insulin)
Corticosteroids can increase blood glucose levels, requiring adjustment of antidiabetic medication.
Anticoagulants (e.g., Warfarin)
May alter the effects of anticoagulants; close monitoring of INR/PT is recommended.
Vaccines (live or live-attenuated)
Avoid during immunosuppressive therapy due to risk of disseminated infection.
CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
Can increase methylprednisolone plasma concentrations, potentially increasing side effects.
CYP3A4 inducers (e.g., Rifampicin, Phenytoin, Carbamazepine)
Can decrease methylprednisolone plasma concentrations, reducing its effectiveness.
Storage
Store below 30°C in a cool, dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare and usually does not cause life-threatening effects. Chronic overdose can lead to symptoms of Cushing's syndrome (e.g., moon face, central obesity, fluid retention). Treatment is symptomatic and supportive. Gradual reduction of dose under medical supervision is crucial for chronic overdose to prevent adrenal insufficiency.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Infants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. Corticosteroids are excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date, depending on the manufacturer and specific formulation.
Availability
Available in pharmacies, hospitals, and clinics worldwide
Approval Status
Approved (FDA, DGDA and various global regulatory bodies)
Patent Status
Generic (off-patent)
WHO Essential Medicine
YesClinical Trials
Methylprednisolone has undergone extensive clinical trials across various indications since its introduction. Ongoing research continues to explore new applications and refine existing treatment protocols, particularly concerning optimal dosing, duration, and management of side effects.
Lab Monitoring
- Blood glucose levels (especially in diabetic or pre-diabetic patients)
- Electrolyte levels (e.g., potassium)
- Blood pressure
- Bone mineral density (for long-term use)
- Ophthalmic examinations (for long-term use, to check for cataracts or glaucoma)
- Growth monitoring in children
Doctor Notes
- Emphasize the importance of gradual tapering of the dose upon discontinuation to prevent adrenal crisis.
- Monitor blood glucose, blood pressure, and bone density, especially in patients on long-term therapy.
- Educate patients on symptoms of infection and adrenal insufficiency.
- Consider prophylactic measures for osteoporosis (e.g., calcium, vitamin D) in high-risk patients on long-term therapy.
Patient Guidelines
- Do not stop taking this medicine abruptly, especially after prolonged use, as it can cause withdrawal symptoms. Always follow your doctor's instructions for tapering the dose.
- Take with food or milk to reduce stomach upset.
- Inform your doctor about any unusual side effects or if your symptoms worsen.
- Avoid close contact with people who are sick or have infections, as corticosteroids can weaken your immune system.
- Carry a steroid treatment card if you are on long-term therapy.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Methylprednisolone may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and vitamin D to support bone health, especially during long-term use.
- Limit sodium intake to manage fluid retention and high blood pressure.
- Engage in regular, moderate exercise to maintain muscle strength and bone density.
- Avoid alcohol and smoking as they can exacerbate gastrointestinal issues and bone loss.
- Report any fever or signs of infection promptly to your doctor.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.