Micagin
Generic Name
Micafungin sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| micagin 50 mg injection | ৳ 4,000.00 | N/A |
Description
Overview of the medicine
Micagin (Micafungin sodium) is an echinocandin antifungal medicine used to treat various severe fungal infections, including invasive candidiasis, candidemia, and esophageal candidiasis.
Uses & Indications
Dosage
Adults
Invasive candidiasis/candidemia: 100 mg IV once daily. Esophageal candidiasis: 150 mg IV once daily. Prophylaxis: 50 mg IV once daily.
Elderly
No dose adjustment is required based on age alone.
Renal_impairment
No dose adjustment is required for patients with renal impairment.
How to Take
Micagin should be administered as a slow intravenous infusion over a period of 1 hour.
Mechanism of Action
Micafungin inhibits the synthesis of β-(1,3)-D-glucan, a key component of the fungal cell wall, leading to osmotic instability and cell lysis. This action is fungicidal against most Candida species and fungistatic against Aspergillus.
Pharmacokinetics
Onset
Rapid onset of action following IV administration.
Excretion
Mainly excreted in feces (major route) and minimally in urine (minor route).
Half life
Approximately 14-17 hours, allowing for once-daily dosing.
Absorption
Administered intravenously, resulting in 100% systemic bioavailability.
Metabolism
Primarily metabolized in the liver via non-CYP pathways, including hydroxylation by aryl sulfatase and catechol O-methyltransferase.
Side Effects
Contraindications
- Hypersensitivity to micafungin, other echinocandins, or any component of the formulation.
Drug Interactions
Sirolimus
Micafungin may increase sirolimus exposure. Monitor sirolimus levels.
Nifedipine
Concurrent use may increase nifedipine exposure. Monitor nifedipine levels and for adverse effects.
Tacrolimus
Micafungin may decrease tacrolimus AUC. Monitor tacrolimus levels.
Cyclosporine
Coadministration with micafungin may increase cyclosporine plasma concentrations. Monitor cyclosporine levels.
Storage
Store unopened vials at controlled room temperature (20-25°C), protected from light. Reconstituted solution is stable for 24-48 hours when refrigerated.
Overdose
There is no specific antidote for micafungin overdose. Management should be supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation as it is unknown if micafungin is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to micafungin, other echinocandins, or any component of the formulation.
Drug Interactions
Sirolimus
Micafungin may increase sirolimus exposure. Monitor sirolimus levels.
Nifedipine
Concurrent use may increase nifedipine exposure. Monitor nifedipine levels and for adverse effects.
Tacrolimus
Micafungin may decrease tacrolimus AUC. Monitor tacrolimus levels.
Cyclosporine
Coadministration with micafungin may increase cyclosporine plasma concentrations. Monitor cyclosporine levels.
Storage
Store unopened vials at controlled room temperature (20-25°C), protected from light. Reconstituted solution is stable for 24-48 hours when refrigerated.
Overdose
There is no specific antidote for micafungin overdose. Management should be supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation as it is unknown if micafungin is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for unopened vials when stored as recommended.
Availability
Available in hospitals and specialized pharmacies
Approval Status
Approved by regulatory bodies (e.g., FDA)
Patent Status
Patent expired for original molecule; generic versions available
Clinical Trials
Extensive clinical trials have evaluated micafungin's efficacy and safety for its approved indications and in various patient populations, including those with compromised immune systems.
Lab Monitoring
- Liver function tests (ALT, AST, alkaline phosphatase, bilirubin)
- Renal function tests (creatinine, BUN)
- Electrolyte levels (potassium)
Doctor Notes
- Ensure proper reconstitution and dilution before administration.
- Administer as a slow IV infusion to minimize histamine-mediated reactions.
- Monitor liver function tests, renal function, and electrolytes, especially during prolonged therapy.
Patient Guidelines
- Ensure the infusion is administered slowly over 1 hour to minimize infusion-related reactions.
- Report any adverse reactions such as rash, itching, fever, or signs of liver problems (e.g., yellowing of skin/eyes, dark urine) to your doctor immediately.
- Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
Missed Dose Advice
If a dose is missed, it should be administered as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Micafungin may cause dizziness in some patients. Patients should be advised to exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Adhere strictly to medical advice and follow-up appointments.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.