Miprofen
Generic Name
Miclofenac 75 mg Tablet
Manufacturer
PharmaCo Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| miclofenac 75 mg tablet | ৳ 11.07 | ৳ 110.73 |
Description
Overview of the medicine
Miclofenac 75 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness caused by various conditions such as arthritis, ankylosing spondylitis, and acute musculoskeletal injuries. It works by blocking the production of certain natural substances in the body that cause inflammation.
Uses & Indications
Dosage
Adults
Usually 75 mg once or twice daily, or as directed by a physician. Max daily dose: 150 mg.
Elderly
Lower doses may be required due to increased risk of side effects. Consult a physician.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe impairment. Consult a physician.
How to Take
Take orally, preferably with or after food, to minimize gastrointestinal discomfort. Do not crush or chew the tablet; swallow whole with water.
Mechanism of Action
Miclofenac acts primarily by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins mediate inflammation, pain, and fever. By inhibiting prostaglandin synthesis, miclofenac reduces inflammation, pain, and fever.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour.
Excretion
Mainly excreted in the urine (approximately 60%) and feces (approximately 30-40%) as metabolites.
Half life
Approximately 1-2 hours (terminal half-life of active metabolites may be longer).
Absorption
Rapidly and completely absorbed after oral administration. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Extensively metabolized in the liver, primarily by hydroxylation and glucuronidation.
Side Effects
Contraindications
- Known hypersensitivity to miclofenac or other NSAIDs (e.g., aspirin-induced asthma)
- Active gastrointestinal ulceration, bleeding, or perforation
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effect, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers
Reduced antihypertensive effect, increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is primarily symptomatic and supportive, including gastric lavage or activated charcoal if recent ingestion. Monitor renal function and electrolyte balance.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm (premature closure of ductus arteriosus). Use with caution in earlier trimesters only if potential benefit outweighs risk. Excreted in breast milk; use during lactation generally not recommended.
Side Effects
Contraindications
- Known hypersensitivity to miclofenac or other NSAIDs (e.g., aspirin-induced asthma)
- Active gastrointestinal ulceration, bleeding, or perforation
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effect, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
ACE Inhibitors / Angiotensin Receptor Blockers
Reduced antihypertensive effect, increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, lethargy, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management is primarily symptomatic and supportive, including gastric lavage or activated charcoal if recent ingestion. Monitor renal function and electrolyte balance.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm (premature closure of ductus arteriosus). Use with caution in earlier trimesters only if potential benefit outweighs risk. Excreted in breast milk; use during lactation generally not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved (Hypothetical)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Hypothetical clinical trials demonstrated efficacy and safety in various pain and inflammatory conditions, with ongoing post-marketing surveillance.
Lab Monitoring
- Complete Blood Count (CBC) regularly, especially during long-term therapy
- Renal function tests (serum creatinine, BUN) periodically
- Liver function tests (ALT, AST) periodically
- Stool occult blood test if gastrointestinal symptoms occur
Doctor Notes
- Consider lowest effective dose for shortest duration to minimize risks.
- Assess cardiovascular and gastrointestinal risk factors before prescribing.
- Monitor renal function, blood pressure, and CBC in patients on long-term therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Take with food or milk to reduce stomach upset.
- Inform your doctor about all other medications you are taking.
- Report any unusual bleeding, persistent stomach pain, or dark stools immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, drowsiness, or visual disturbances in some patients. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption, as it may increase the risk of stomach irritation and bleeding.
- Maintain a balanced diet and stay hydrated.
- Regular exercise, if appropriate for your condition.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.