Midita
Generic Name
Miditapram Hydrochloride
Manufacturer
PharmaCorp Bangladesh
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| midita 100 mg tablet | ৳ 77.00 | ৳ 308.00 |
Description
Overview of the medicine
Midita 100 mg tablet contains Miditapram Hydrochloride, a selective serotonin reuptake inhibitor (SSRI) used to treat depression, anxiety disorders, and panic disorder. It works by increasing the level of serotonin in the brain, which helps to improve mood and reduce feelings of anxiety.
Uses & Indications
Dosage
Adults
Initial dose 50 mg once daily, preferably in the morning. May be increased to 100 mg once daily after several weeks if needed, based on clinical response and tolerability.
Elderly
A lower starting dose of 25 mg once daily may be considered. Dose titration should be gradual and carefully monitored.
Renal_impairment
No specific dose adjustment is generally required for mild to moderate renal impairment. Caution is advised in severe renal impairment (CrCl < 30 mL/min).
How to Take
Midita 100 mg tablet should be taken orally, with or without food. It is recommended to take it at the same time each day to maintain consistent drug levels.
Mechanism of Action
Miditapram selectively inhibits the reuptake of serotonin (5-HT) into presynaptic neurons, thereby increasing the concentration of serotonin in the synaptic cleft. This leads to enhanced serotonergic neurotransmission in the central nervous system, which is believed to be responsible for its antidepressant and anxiolytic effects.
Pharmacokinetics
Onset
Initial clinical improvement may be seen within 1-2 weeks, but full antidepressant effect takes 2-4 weeks.
Excretion
Mainly excreted via the kidneys (urine) and to a lesser extent through feces.
Half life
Approximately 24-36 hours.
Absorption
Well absorbed orally; peak plasma concentrations reached within 4-8 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2D6 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Miditapram or any excipients.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOIs.
- Concomitant use with pimozide.
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability, mental status changes).
NSAIDs
Increased risk of gastrointestinal bleeding.
Alcohol
Should be avoided as it may potentiate central nervous system depressant effects.
Lithium
Potential for increased serotonin syndrome risk and neurotoxicity.
Triptans
Increased risk of serotonin syndrome.
Warfarin
Increased risk of bleeding due to potential enhancement of anticoagulant effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, somnolence, tachycardia, tremor, agitation, and dizziness. Severe overdose can lead to seizures, serotonin syndrome, and coma. Treatment is symptomatic and supportive. Maintain an open airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, caution should be exercised when Midita is administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Miditapram or any excipients.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOIs.
- Concomitant use with pimozide.
Drug Interactions
MAOIs
Risk of serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability, mental status changes).
NSAIDs
Increased risk of gastrointestinal bleeding.
Alcohol
Should be avoided as it may potentiate central nervous system depressant effects.
Lithium
Potential for increased serotonin syndrome risk and neurotoxicity.
Triptans
Increased risk of serotonin syndrome.
Warfarin
Increased risk of bleeding due to potential enhancement of anticoagulant effects.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, somnolence, tachycardia, tremor, agitation, and dizziness. Severe overdose can lead to seizures, serotonin syndrome, and coma. Treatment is symptomatic and supportive. Maintain an open airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, caution should be exercised when Midita is administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by Regulatory Authority
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive randomized, placebo-controlled clinical trials have demonstrated the efficacy and safety of Miditapram in the treatment of Major Depressive Disorder and various anxiety disorders.
Lab Monitoring
- Monitor serum sodium levels, especially in elderly patients or those on diuretics, due to risk of hyponatremia.
- Liver function tests (LFTs) may be considered in patients with pre-existing hepatic impairment or during prolonged treatment.
Doctor Notes
- Monitor for suicidal ideation and behavior, especially during initial therapy and dose adjustments.
- Assess for symptoms of serotonin syndrome if co-administered with other serotonergic agents.
- Counsel patients on the importance of gradual discontinuation to prevent withdrawal symptoms.
Patient Guidelines
- Do not stop taking Midita abruptly; gradual tapering is necessary to avoid withdrawal symptoms.
- Report any new or worsening depression, suicidal thoughts, or unusual changes in mood or behavior to your doctor immediately.
- It may take several weeks to experience the full therapeutic benefits of Midita.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Midita may cause dizziness, drowsiness, or impaired judgment, especially at the beginning of treatment. Patients should be advised to exercise caution when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Avoid alcohol consumption while taking Midita as it may increase side effects and impair judgment.
- Regular exercise and a balanced diet can complement the treatment.
- Practice stress-reduction techniques like meditation or yoga.
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