Migon
Generic Name
Flunarizine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| migon 10 mg tablet | ৳ 5.00 | ৳ 70.00 |
Description
Overview of the medicine
Flunarizine is a selective calcium entry blocker with anti-migraine properties, used for the prophylaxis of classical (with aura) or common (without aura) migraine. It also has antihistaminic and sedative effects.
Uses & Indications
Dosage
Adults
5-10 mg orally once daily, usually at bedtime. Maximum 10 mg/day. A common regimen is 10 mg at night for migraine prophylaxis.
Elderly
Initiate with 5 mg once daily, adjust carefully. Monitor for side effects.
Renal_impairment
No specific dose adjustment generally needed, but use with caution.
How to Take
Orally, with water, preferably at bedtime.
Mechanism of Action
Blocks calcium influx into vascular smooth muscle and cerebral cells, inhibits vasoconstriction caused by various agents, and has antihistaminic, sedative, and anti-vertiginous properties.
Pharmacokinetics
Onset
Gradual, for prophylaxis, effects are typically seen after several weeks of continuous use.
Excretion
Primarily excreted via bile in feces.
Half life
Long, varies from 5 to 18 days, allowing once-daily dosing.
Absorption
Well absorbed after oral administration. Peak plasma levels usually reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP2D6.
Side Effects
Contraindications
- Depressive illness or history of recurrent depressive episodes
- Pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders
- Hypersensitivity to flunarizine
Drug Interactions
Antidepressants
May exacerbate depressive symptoms; use with caution.
Phenytoin/Carbamazepine
May alter flunarizine plasma levels, monitoring recommended.
Sedatives/Hypnotics/Alcohol
Increased sedation due to additive depressant effects.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms include sedation, agitation, tachycardia. Management is symptomatic and supportive; gastric lavage may be considered.
Pregnancy & Lactation
Avoid during pregnancy unless absolutely necessary and benefits outweigh risks. Excreted in breast milk, so avoid during lactation or discontinue breastfeeding.
Side Effects
Contraindications
- Depressive illness or history of recurrent depressive episodes
- Pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders
- Hypersensitivity to flunarizine
Drug Interactions
Antidepressants
May exacerbate depressive symptoms; use with caution.
Phenytoin/Carbamazepine
May alter flunarizine plasma levels, monitoring recommended.
Sedatives/Hypnotics/Alcohol
Increased sedation due to additive depressant effects.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms include sedation, agitation, tachycardia. Management is symptomatic and supportive; gastric lavage may be considered.
Pregnancy & Lactation
Avoid during pregnancy unless absolutely necessary and benefits outweigh risks. Excreted in breast milk, so avoid during lactation or discontinue breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Flunarizine has been extensively studied for migraine prophylaxis in numerous clinical trials demonstrating its efficacy and tolerability.
Lab Monitoring
- Regular monitoring for depressive symptoms, especially in susceptible individuals.
- Monitor for extrapyramidal symptoms (tremor, rigidity, bradykinesia).
Doctor Notes
- Consider dose reduction or discontinuation if depression or extrapyramidal symptoms occur.
- Advise patients on the importance of adherence for prophylaxis and potential side effects.
- Re-evaluate treatment periodically, e.g., after 6 months, to assess necessity and minimize long-term risks.
Patient Guidelines
- Take at bedtime to minimize drowsiness during the day.
- Do not stop abruptly without consulting a doctor.
- Report any mood changes or unusual movements immediately.
- It may take several weeks to see the full benefit for migraine prophylaxis.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it's almost time for the next dose. Do not double the dose.
Driving Precautions
May cause drowsiness, dizziness. Patients should be warned not to drive or operate machinery until they know how they react to the medication.
Lifestyle Advice
- Avoid alcohol during treatment.
- Maintain a regular sleep schedule.
- Stay hydrated.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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