Mikotrim
Generic Name
Co-trimoxazole (Sulfamethoxazole + Trimethoprim)
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mikotrim 200 mg suspension | ৳ 21.25 | N/A |
Description
Overview of the medicine
Co-trimoxazole is an antibiotic used to treat various bacterial infections. It combines two active ingredients, sulfamethoxazole and trimethoprim, which work synergistically to inhibit bacterial growth. It is commonly used for urinary tract infections, respiratory tract infections, and certain other bacterial infections.
Uses & Indications
Dosage
Adults
Standard adult dosage for Co-trimoxazole is often Sulfamethoxazole 800 mg + Trimethoprim 160 mg every 12 hours. For suspension, dosage will be adjusted based on the specific infection and patient's weight/age.
Elderly
Dosage adjustment may be required based on renal function and careful monitoring is recommended.
Renal_impairment
Significant dosage reduction or increased dosing interval required based on creatinine clearance.
How to Take
Oral, with or without food. Ensure adequate fluid intake to prevent crystalluria. Shake well before use. Follow your doctor's instructions regarding dose and duration.
Mechanism of Action
Sulfamethoxazole inhibits bacterial dihydrofolate synthesis, while trimethoprim inhibits bacterial dihydrofolate reductase. This dual blockade of folic acid metabolism leads to synergistic antibacterial action.
Pharmacokinetics
Onset
Within 1-4 hours (antibacterial activity).
Excretion
Primarily renal, with both unchanged drug and metabolites excreted in urine.
Half life
Sulfamethoxazole: 9-11 hours; Trimethoprim: 8-10 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached within 1-4 hours.
Metabolism
Primarily hepatic (acetylation and glucuronidation for sulfamethoxazole, oxidation and hydroxylation for trimethoprim).
Side Effects
Contraindications
- •Hypersensitivity to sulfamethoxazole or trimethoprim or any component.
- •Severe renal or hepatic impairment.
- •Megaloblastic anemia due to folate deficiency.
- •Infants less than 2 months of age.
Drug Interactions
Warfarin
Increased anticoagulant effect due to inhibition of warfarin metabolism.
Methotrexate
Increased risk of methotrexate toxicity due to reduced renal excretion.
Diuretics (thiazides)
Increased risk of thrombocytopenia in elderly patients.
Potassium-sparing diuretics/ACE inhibitors
Increased risk of hyperkalemia due to trimethoprim's effect on renal potassium excretion.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Do not refrigerate after reconstitution unless specifically instructed.
Overdose
Symptoms include nausea, vomiting, dizziness, headache, mental depression, bone marrow depression. Treatment involves gastric lavage, emesis, and supportive measures. Leucovorin may be administered to counteract folate deficiency.
Pregnancy & Lactation
Pregnancy: Category C. Use only if potential benefit outweighs potential risk to the fetus. Folate supplementation may be considered. Lactation: Excreted in breast milk. Generally not recommended, especially for premature infants or those with hyperbilirubinemia, due to the risk of kernicterus.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when unopened. Once reconstituted, typically 7-14 days when stored as directed.
Availability
Pharmacies nationwide
Approval Status
Approved (Generic)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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