Milk of Magnesia Plus
Generic Name
Magnesium Hydroxide + Simethicone Emulsion
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| milk of magnesia plus 300 mg emulsion | ৳ 95.29 | N/A |
Description
Overview of the medicine
Milk of Magnesia Plus 300 mg Emulsion is a combination medication used to relieve indigestion, heartburn, sour stomach, constipation, and gas. It contains Magnesium Hydroxide, which acts as an antacid and saline laxative, and Simethicone, an antiflatulent that helps to break up gas bubbles.
Uses & Indications
Dosage
Adults
10-20 mL orally, 3-4 times daily after meals and at bedtime, or as directed by a physician. Shake well before use.
Elderly
Similar to adult dosage, but caution with prolonged use due to potential for electrolyte imbalance or renal impairment. Consult a doctor.
Renal_impairment
Reduced dosage or avoid in severe renal impairment due to risk of hypermagnesemia.
How to Take
Administer orally. Shake the bottle well before each use. Can be taken with water.
Mechanism of Action
Magnesium Hydroxide neutralizes stomach acid by reacting with hydrochloric acid to form water and magnesium chloride. It also draws water into the intestines, causing osmotic pressure that stimulates bowel movements (laxative effect). Simethicone works by altering the surface tension of gas bubbles in the gastrointestinal tract, causing them to coalesce and be more easily expelled.
Pharmacokinetics
Onset
Antacid: Minutes; Laxative: 30 minutes to 6 hours; Simethicone: Rapid.
Excretion
Magnesium: Primarily renally excreted for absorbed portion, unabsorbed portion excreted in feces. Simethicone: Excreted unchanged in feces.
Half life
Magnesium: Varies, excreted by kidneys. Simethicone: Not applicable (unabsorbed).
Absorption
Magnesium Hydroxide: Magnesium ions are minimally absorbed from the GI tract (approximately 15-30%), while hydroxide is not absorbed. Simethicone: Not absorbed from the GI tract.
Metabolism
Magnesium: Not metabolized, physiological ion. Simethicone: Not metabolized.
Side Effects
Contraindications
- Hypersensitivity to any component
- Severe abdominal pain
- Appendicitis
- Bowel obstruction
- Severe renal impairment
Drug Interactions
Iron salts & Digoxin
May reduce absorption; separate administration by 2-4 hours.
Enteric-coated medications
May cause premature dissolution.
Tetracyclines & Fluoroquinolones
May reduce absorption; separate administration by 2-4 hours.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms of overdose (hypermagnesemia) may include nausea, vomiting, flushing, muscle weakness, hypotension, bradycardia, CNS depression, respiratory depression, and coma. Management involves supportive care, intravenous calcium gluconate to counteract magnesium effects, and diuretics or dialysis in severe cases.
Pregnancy & Lactation
Generally considered safe in moderate doses, but consult a doctor or pharmacist before use during pregnancy or lactation.
Side Effects
Contraindications
- Hypersensitivity to any component
- Severe abdominal pain
- Appendicitis
- Bowel obstruction
- Severe renal impairment
Drug Interactions
Iron salts & Digoxin
May reduce absorption; separate administration by 2-4 hours.
Enteric-coated medications
May cause premature dissolution.
Tetracyclines & Fluoroquinolones
May reduce absorption; separate administration by 2-4 hours.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep the bottle tightly closed.
Overdose
Symptoms of overdose (hypermagnesemia) may include nausea, vomiting, flushing, muscle weakness, hypotension, bradycardia, CNS depression, respiratory depression, and coma. Management involves supportive care, intravenous calcium gluconate to counteract magnesium effects, and diuretics or dialysis in severe cases.
Pregnancy & Lactation
Generally considered safe in moderate doses, but consult a doctor or pharmacist before use during pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date, check expiry date on package.
Availability
Pharmacies, Supermarkets
Approval Status
Approved for OTC use
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
The active ingredients, Magnesium Hydroxide and Simethicone, are well-established and have been in clinical use for decades. Extensive clinical trials have confirmed their efficacy and safety for their indicated uses.
Lab Monitoring
- Monitor serum magnesium levels in patients with renal impairment or prolonged use.
- Monitor electrolyte balance.
Doctor Notes
- Advise patients on the importance of proper dosing and not exceeding the recommended dose.
- Counsel patients on potential drug interactions, especially with antibiotics and iron supplements.
- Monitor for signs of hypermagnesemia in patients with renal impairment or chronic use.
- Emphasize lifestyle modifications for better GI health.
Patient Guidelines
- Shake well before each use.
- Do not exceed the recommended dose.
- If symptoms persist for more than 2 weeks, consult a doctor.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in fiber to prevent constipation.
- Drink adequate fluids (6-8 glasses of water daily).
- Engage in regular physical activity.
- Avoid trigger foods that worsen indigestion or gas.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.