mini-28
Generic Name
Ethinyl Estradiol 0.03 mg and Levonorgestrel 0.15 mg Tablet
Manufacturer
Reputable Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mini 28 003 mg tablet | ৳ 23.52 | N/A |
Description
Overview of the medicine
mini-28 is a combined oral contraceptive pill used to prevent pregnancy. It contains two hormones, Ethinyl Estradiol (an estrogen) and Levonorgestrel (a progestin), which work together to inhibit ovulation.
Uses & Indications
Dosage
Adults
One active tablet daily for 21 days, followed by 7 placebo tablets, or 7-day pill-free interval. Start new pack after 28 days.
Elderly
Not indicated for postmenopausal women.
Renal_impairment
No specific dosage adjustment required, but caution advised.
How to Take
Take one tablet orally at the same time each day, starting on the first day of menstruation or as directed by a healthcare provider.
Mechanism of Action
Works primarily by inhibiting ovulation, thickening cervical mucus to prevent sperm penetration, and altering the uterine lining to prevent implantation.
Pharmacokinetics
Onset
Contraceptive effect usually begins after 7 consecutive days of active pill intake if started on the first day of menstruation.
Excretion
Metabolites primarily excreted in urine and feces.
Half life
Ethinyl Estradiol: 18-24 hours; Levonorgestrel: 24-30 hours.
Absorption
Both Ethinyl Estradiol and Levonorgestrel are rapidly and almost completely absorbed after oral administration.
Metabolism
Primarily hepatic, extensive first-pass metabolism for Ethinyl Estradiol.
Side Effects
Contraindications
- History of blood clots (DVT, PE)
- Active liver disease
- Undiagnosed vaginal bleeding
- Breast cancer or other estrogen-sensitive cancers
- Migraine with aura
- Uncontrolled hypertension
- Severe diabetes with vascular complications
Drug Interactions
Grapefruit juice
May increase Ethinyl Estradiol levels.
Antibiotics (e.g., Rifampicin)
May reduce contraceptive efficacy by affecting gut flora or liver enzymes.
Ritonavir-boosted Protease Inhibitors
May alter hormone levels.
Anticonvulsants (e.g., Phenytoin, Carbamazepine)
May reduce contraceptive efficacy due to enzyme induction.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose may cause nausea, vomiting, and withdrawal bleeding in females. No specific antidote; symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Contraindicated in pregnancy. Small amounts of hormones may pass into breast milk; generally not recommended during lactation, especially in the first 6 weeks postpartum, as it may affect milk supply. Progestin-only pills may be a better option for breastfeeding mothers after the initial period.
Side Effects
Contraindications
- History of blood clots (DVT, PE)
- Active liver disease
- Undiagnosed vaginal bleeding
- Breast cancer or other estrogen-sensitive cancers
- Migraine with aura
- Uncontrolled hypertension
- Severe diabetes with vascular complications
Drug Interactions
Grapefruit juice
May increase Ethinyl Estradiol levels.
Antibiotics (e.g., Rifampicin)
May reduce contraceptive efficacy by affecting gut flora or liver enzymes.
Ritonavir-boosted Protease Inhibitors
May alter hormone levels.
Anticonvulsants (e.g., Phenytoin, Carbamazepine)
May reduce contraceptive efficacy due to enzyme induction.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose may cause nausea, vomiting, and withdrawal bleeding in females. No specific antidote; symptomatic and supportive treatment is recommended.
Pregnancy & Lactation
Contraindicated in pregnancy. Small amounts of hormones may pass into breast milk; generally not recommended during lactation, especially in the first 6 weeks postpartum, as it may affect milk supply. Progestin-only pills may be a better option for breastfeeding mothers after the initial period.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical data available supporting the efficacy and safety of combined oral contraceptives for pregnancy prevention, with ongoing post-market surveillance.
Lab Monitoring
- Blood pressure monitoring (regularly)
- Lipid profile (periodically)
- Glucose tolerance test (periodically, especially with risk factors)
- Liver function tests (if clinically indicated)
Doctor Notes
- Thoroughly assess patient's medical history, particularly cardiovascular risk factors, before prescribing.
- Provide clear instructions on proper usage and management of missed pills.
- Counsel on the importance of adherence for contraceptive efficacy and the lack of STI protection.
- Schedule regular follow-up appointments for blood pressure checks and overall health assessment.
Patient Guidelines
- Take exactly as directed, preferably at the same time each day.
- Do not skip pills, especially active ones. Follow missed pill instructions carefully.
- Use backup contraception (e.g., condoms) if pills are missed or when starting a new medication that may interact.
- Report any unusual or severe symptoms (e.g., severe leg pain, chest pain, sudden vision changes) to your doctor immediately.
- Regular gynecological check-ups are recommended.
Missed Dose Advice
If one active pill is missed, take it as soon as remembered and continue with the next pill at the usual time. If more than one active pill is missed, refer to package insert or consult a doctor for specific instructions and consider backup contraception.
Driving Precautions
mini-28 is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Quit smoking completely to significantly reduce cardiovascular risks.
- Maintain a healthy diet and regular exercise to manage weight and overall health.
- Discuss all current medications and supplements with your doctor to avoid interactions.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.