Minzin
Generic Name
Levocetirizine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| minzin syrup | ৳ 65.00 | N/A |
Description
Overview of the medicine
Minzin (Levocetirizine) is a non-sedating antihistamine used to relieve symptoms of allergic rhinitis (e.g., sneezing, runny nose) and chronic idiopathic urticaria (hives).
Uses & Indications
Dosage
Adults
5 mg once daily, in the evening.
Elderly
No dose adjustment required unless renal function is impaired.
Renal_impairment
Dose adjustment required based on creatinine clearance (e.g., 2.5 mg every other day for moderate impairment).
How to Take
Oral, with or without food. Recommended to take in the evening.
Mechanism of Action
Levocetirizine, the R-enantiomer of cetirizine, is a potent and selective antagonist of peripheral H1-receptors. It inhibits histamine-induced effects by blocking the binding of histamine to H1 receptors.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted unchanged in the urine (85.4% of dose).
Half life
Approximately 7-10 hours
Absorption
Rapidly and extensively absorbed after oral administration, peak plasma concentrations reached within 0.9 hours.
Metabolism
Very little metabolism in the liver (<14% of the dose).
Side Effects
Contraindications
- Hypersensitivity to levocetirizine or any component of the formulation
- End-stage renal disease (CrCl < 10 mL/min)
Drug Interactions
Ritonavir
May increase plasma levels of levocetirizine.
CNS depressants (e.g., alcohol, sedatives)
May increase drowsiness.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness in adults and agitation/restlessness followed by drowsiness in children. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, so caution is advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to levocetirizine or any component of the formulation
- End-stage renal disease (CrCl < 10 mL/min)
Drug Interactions
Ritonavir
May increase plasma levels of levocetirizine.
CNS depressants (e.g., alcohol, sedatives)
May increase drowsiness.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include drowsiness in adults and agitation/restlessness followed by drowsiness in children. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, so caution is advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Available in all pharmacies
Approval Status
Approved by DGDA and international bodies
Patent Status
Off-patent (Generic available)
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of levocetirizine for its approved indications.
Lab Monitoring
- No specific routine lab monitoring required.
Doctor Notes
- Assess renal function before prescribing, especially in elderly patients.
- Counsel patients on potential drowsiness and interaction with alcohol.
- Review concomitant medications for potential interactions.
Patient Guidelines
- Take this medicine in the evening, with or without food.
- Avoid alcohol or other CNS depressants as they may increase drowsiness.
- Do not exceed the recommended dose.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens.
- Maintain good indoor air quality.
- Consult doctor if symptoms persist.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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