Miraflo
Generic Name
Mirabegron
Manufacturer
Drug Manufacturer
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| miraflo 25 mg tablet | ৳ 30.00 | ৳ 300.00 |
Description
Overview of the medicine
Mirabegron 25 mg tablet is a beta-3 adrenergic agonist used to treat symptoms of overactive bladder (OAB), such as urgent need to urinate, frequent urination, and inability to control urination.
Uses & Indications
Dosage
Adults
Initial dose of 25 mg once daily, may be increased to 50 mg once daily based on efficacy and tolerability.
Elderly
No dose adjustment required for elderly patients.
Renal_impairment
Mild-to-moderate impairment: 25 mg once daily. Severe impairment: Not recommended.
How to Take
Take orally once daily with water, with or without food. Do not chew, crush, or break the tablet.
Mechanism of Action
Mirabegron activates beta-3 adrenergic receptors in the bladder, leading to relaxation of the detrusor muscle during the storage phase of the urinary bladder cycle, thereby increasing bladder capacity.
Pharmacokinetics
Onset
Clinical effects typically seen within 8 weeks, with some improvement within days.
Excretion
Renal (approximately 55%) and fecal (approximately 34%).
Half life
Approximately 32 hours.
Absorption
Peak plasma concentrations reached in 3.5 to 4 hours. Absolute bioavailability is 29% for 25 mg.
Metabolism
Metabolized by multiple pathways including N-dealkylation, O-dealkylation, glucuronidation, and amide hydrolysis, primarily by CYP3A4, CYP2D6, butyrylcholinesterase, and UGT.
Side Effects
Contraindications
- Hypersensitivity to Mirabegron or any excipients.
- Uncontrolled severe hypertension (systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg).
Drug Interactions
Warfarin
Monitor INR.
Metoprolol, Desipramine, Digoxin, Propafenone, Flecainide
Mirabegron is a moderate CYP2D6 inhibitor, may increase exposure of CYP2D6 substrates.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include palpitations and increased pulse rate. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to fetus. Excreted in animal milk, unknown in human milk. Caution advised.
Side Effects
Contraindications
- Hypersensitivity to Mirabegron or any excipients.
- Uncontrolled severe hypertension (systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg).
Drug Interactions
Warfarin
Monitor INR.
Metoprolol, Desipramine, Digoxin, Propafenone, Flecainide
Mirabegron is a moderate CYP2D6 inhibitor, may increase exposure of CYP2D6 substrates.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include palpitations and increased pulse rate. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to fetus. Excreted in animal milk, unknown in human milk. Caution advised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Patent protected (brand specific)
Clinical Trials
Extensive clinical trials have established its efficacy and safety for OAB.
Lab Monitoring
- Blood pressure monitoring, especially in patients with pre-existing hypertension.
Doctor Notes
- Monitor blood pressure regularly, especially at treatment initiation.
- Assess for signs of urinary retention during therapy.
Patient Guidelines
- Take as directed by your doctor, do not stop without consulting.
- Inform your doctor about all existing medical conditions and medications.
- Report any increase in blood pressure or heart rate.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose.
Driving Precautions
Mirabegron is not expected to affect the ability to drive or use machines.
Lifestyle Advice
- Maintain a healthy fluid intake.
- Avoid excessive caffeine and alcohol.
- Avoid bladder irritants like spicy foods and carbonated drinks.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.