For ulcer prevention, take orally with food. For obstetric uses, it may be administered orally, sublingually, or vaginally as directed by a healthcare professional. Do not crush or chew tablets for vaginal use.

Misoprostol binds to prostaglandin receptors on parietal cells, inhibiting gastric acid secretion. It also enhances mucosal defense by increasing bicarbonate and mucus secretion and improving mucosal blood flow. In the uterus, it causes myometrial contractions and cervical ripening.

• •Known hypersensitivity to misoprostol or other prostaglandins.
• •Pregnancy (except when used for medical abortion or labor induction under strict medical supervision).
• •In women of childbearing potential, if not using effective contraception for ulcer prevention.

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of overdose may include sedation, tremor, convulsions, dyspnea, abdominal pain, diarrhea, fever, palpitations, hypotension, and bradycardia. Treatment is supportive and symptomatic; there is no specific antidote.

Highly contraindicated in pregnancy unless its use is specifically for termination of pregnancy or induction of labor under medical supervision. It is excreted in breast milk; use with caution during lactation, or consider alternative feeding methods.