Molukat
Generic Name
Montelukast
Manufacturer
Drug International Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| molukat 4 mg chewable tablet | ৳ 6.02 | N/A |
Description
Overview of the medicine
Molukat 4 mg Chewable Tablet contains Montelukast, a leukotriene receptor antagonist used for the treatment of asthma and allergic rhinitis, primarily in pediatric patients.
Uses & Indications
Dosage
Adults
Not typically indicated for adults at this strength; adults usually take 10 mg.
Elderly
Not typically indicated for elderly at this strength; elderly usually take 10 mg.
Renal_impairment
No dosage adjustment necessary for renal impairment.
Children (2-5 years)
One 4 mg chewable tablet daily, to be taken in the evening.
How to Take
Take orally once daily in the evening. For chewable tablets, chew completely before swallowing. Can be taken with or without food.
Mechanism of Action
Montelukast selectively antagonizes the cysteinyl leukotriene 1 (CysLT1) receptor, inhibiting the actions of leukotrienes. Leukotrienes are potent inflammatory mediators involved in the pathophysiology of asthma and allergic rhinitis.
Pharmacokinetics
Onset
Within 1 day (for asthma symptom improvement)
Excretion
Primarily excreted in feces via bile (86%), less than 0.2% in urine.
Half life
Approximately 2.7 to 5.5 hours
Absorption
Rapidly absorbed after oral administration. Mean oral bioavailability is 64%.
Metabolism
Extensively metabolized in the liver by CYP2C8, CYP3A4, and CYP2C9.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation
Drug Interactions
Rifampin
May decrease plasma concentrations of montelukast, requiring careful monitoring.
Phenobarbital
May decrease the AUC of montelukast, requiring dose adjustment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms usually mild (e.g., abdominal pain, somnolence, thirst, headache, vomiting, psychomotor hyperactivity). Symptomatic and supportive treatment is recommended. No specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed after consulting a doctor. Excreted in breast milk, caution advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation
Drug Interactions
Rifampin
May decrease plasma concentrations of montelukast, requiring careful monitoring.
Phenobarbital
May decrease the AUC of montelukast, requiring dose adjustment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms usually mild (e.g., abdominal pain, somnolence, thirst, headache, vomiting, psychomotor hyperactivity). Symptomatic and supportive treatment is recommended. No specific antidote.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed after consulting a doctor. Excreted in breast milk, caution advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date, as indicated on the pack.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by FDA (US), DGDA (Bangladesh)
Patent Status
Generic available (original patent expired)
Clinical Trials
Numerous clinical trials have established the efficacy and safety of Montelukast for asthma and allergic rhinitis across various age groups, supporting its use as a long-term control medication.
Lab Monitoring
- Liver function tests (LFTs) if liver dysfunction suspected. No routine lab monitoring is generally required.
Doctor Notes
- Counsel parents on proper chewable tablet administration and the importance of continuous therapy.
- Monitor for neuropsychiatric symptoms, especially in pediatric patients, and educate parents about these potential side effects.
- Montelukast is a prophylactic treatment and is not intended for the relief of acute asthma attacks; patients should have appropriate rescue medication.
Patient Guidelines
- Take as directed by your doctor, usually once daily in the evening.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Chew the tablet completely before swallowing.
- Report any mood or behavior changes to your doctor immediately, especially in children.
- This medicine is not for acute asthma attacks.
Missed Dose Advice
If a dose is missed, take the next dose at the usual time. Do not double the dose to compensate for a missed one.
Driving Precautions
May cause dizziness or drowsiness; caution advised when driving or operating machinery. If affected, avoid such activities.
Lifestyle Advice
- Maintain a healthy lifestyle, including regular exercise (if appropriate) and a balanced diet.
- Avoid known allergens that trigger asthma or allergic rhinitis.
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