Monasic
Generic Name
Monacic Acid
Manufacturer
Healthwell Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| monasic 10 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Monasic 10 mg tablet contains Monacic Acid, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is prescribed for conditions such as osteoarthritis, rheumatoid arthritis, muscle pain, and menstrual pain.
Uses & Indications
Dosage
Adults
10 mg orally, two to three times daily, preferably after meals. Maximum daily dose should not exceed 30 mg.
Elderly
Lower doses may be required, generally 10 mg once or twice daily, due to increased risk of adverse effects and reduced renal function. Close monitoring is recommended.
Renal_impairment
Use with caution. For moderate impairment, consider reducing the dose to 10 mg once daily. Not recommended in severe renal impairment (CrCl < 30 mL/min).
Hepatic_impairment
Use with caution. Lower doses may be necessary. Not recommended in severe hepatic impairment.
How to Take
Take the tablet orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water, do not chew or crush it.
Mechanism of Action
Monacic Acid works by inhibiting the synthesis of prostaglandins, which are chemicals in the body that contribute to pain, inflammation, and fever. It primarily achieves this by inhibiting cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2.
Pharmacokinetics
Onset
Pain relief usually starts within 30-60 minutes.
Excretion
Mainly excreted through the urine (60-70%) as metabolites, with a smaller portion (30-40%) excreted in feces via bile.
Half life
Approximately 2-4 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1-2 hours after oral administration.
Metabolism
Primarily metabolized in the liver by cytochrome P450 enzymes (e.g., CYP2C9) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Monacic Acid or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced efficacy of these drugs and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In severe cases, respiratory depression, coma, and acute renal failure may occur. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Monasic Acid is contraindicated during the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus and potential renal dysfunction. In early pregnancy and during lactation, use only if clearly needed and the potential benefit outweighs the risk. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Monacic Acid or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced efficacy of these drugs and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
SSRIs (Selective Serotonin Reuptake Inhibitors)
Increased risk of gastrointestinal bleeding.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. In severe cases, respiratory depression, coma, and acute renal failure may occur. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered within an hour of ingestion.
Pregnancy & Lactation
Monasic Acid is contraindicated during the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus and potential renal dysfunction. In early pregnancy and during lactation, use only if clearly needed and the potential benefit outweighs the risk. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Various clinical trials have established the efficacy and safety of Monacic Acid for its indicated uses, with post-marketing surveillance continuing to monitor its long-term effects.
Lab Monitoring
- Regular monitoring of renal function (serum creatinine, BUN) in patients on long-term therapy or with pre-existing renal impairment.
- Liver function tests (ALT, AST) periodically for patients on prolonged treatment.
- Complete blood count (CBC) to monitor for blood dyscrasias, especially with prolonged use.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for signs and symptoms of GI bleeding or cardiovascular events.
- Assess renal function periodically, especially in elderly or high-risk patients.
- Advise patients to report any unusual symptoms, especially related to the GI tract or cardiovascular system.
Patient Guidelines
- Take Monasic 10 mg with food or milk to prevent stomach upset.
- Do not exceed the recommended dose to avoid potential side effects.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Avoid alcohol consumption while taking this medicine.
- Seek immediate medical attention if you experience severe abdominal pain, black tarry stools, or unusual bleeding/bruising.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Monasic may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating heavy machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and stay hydrated.
- Engage in regular, moderate exercise if advised by your doctor.
- Avoid smoking, as it can worsen gastrointestinal risks associated with NSAIDs.
- Limit alcohol intake.
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