Movigel
Generic Name
Diacerein
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| movigel 02 2 topical gel | N/A | N/A |
Description
Overview of the medicine
Movigel (Diacerein) is a slow-acting drug used to treat osteoarthritis, improving joint function and reducing pain and stiffness.
Uses & Indications
Dosage
Adults
Initially 50 mg once daily with food for 2-4 weeks, then increased to 50 mg twice daily with food.
Elderly
Same as adults, but caution with renal impairment.
Renal_impairment
Dose reduction necessary; e.g., 50 mg once daily if creatinine clearance is <30 ml/min.
How to Take
Take orally with food to improve absorption and reduce gastrointestinal side effects. Swallow capsule whole, do not open or chew.
Mechanism of Action
Diacerein inhibits the production and activity of the pro-inflammatory cytokine Interleukin-1 beta (IL-1β) and reduces cartilage degradation.
Pharmacokinetics
Onset
Slow onset of action, therapeutic effects typically observed after 2-4 weeks of treatment.
Excretion
Primarily excreted renally as rhein and its glucuronide and sulfate conjugates.
Half life
Rhein has an elimination half-life of 4-8 hours.
Absorption
Well absorbed orally, undergoes extensive first-pass metabolism to the active metabolite rhein.
Metabolism
Extensively metabolized to rhein in the liver and gut, followed by conjugation.
Side Effects
Contraindications
- Hypersensitivity to diacerein or anthraquinone derivatives.
- Inflammatory bowel disease (ulcerative colitis, Crohn's disease).
- Pseudo-obstruction, uncompensated hepatic impairment.
- Pregnancy and lactation.
Drug Interactions
Antacids
May reduce absorption of diacerein.
Diuretics
Concomitant use may lead to potassium loss, especially with loop diuretics.
Laxatives
Increased risk of diarrhea.
Other NSAIDs
No specific interactions, but generally not recommended for co-administration due to similar indication.
Storage
Store below 30°C, in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe diarrhea. Management is symptomatic, including fluid and electrolyte replacement.
Pregnancy & Lactation
Diacerein is contraindicated during pregnancy and lactation due to lack of sufficient safety data.
Side Effects
Contraindications
- Hypersensitivity to diacerein or anthraquinone derivatives.
- Inflammatory bowel disease (ulcerative colitis, Crohn's disease).
- Pseudo-obstruction, uncompensated hepatic impairment.
- Pregnancy and lactation.
Drug Interactions
Antacids
May reduce absorption of diacerein.
Diuretics
Concomitant use may lead to potassium loss, especially with loop diuretics.
Laxatives
Increased risk of diarrhea.
Other NSAIDs
No specific interactions, but generally not recommended for co-administration due to similar indication.
Storage
Store below 30°C, in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe diarrhea. Management is symptomatic, including fluid and electrolyte replacement.
Pregnancy & Lactation
Diacerein is contraindicated during pregnancy and lactation due to lack of sufficient safety data.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, refer to product packaging for specific details.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Extensive clinical trials have demonstrated diacerein's efficacy and safety in osteoarthritis. Ongoing post-marketing surveillance and studies continue to monitor its long-term effects.
Lab Monitoring
- Liver function tests (ALT, AST, alkaline phosphatase, bilirubin) before treatment and periodically during treatment, especially in elderly and those with hepatic impairment history.
- Renal function (creatinine clearance) in elderly patients or those with kidney problems.
Doctor Notes
- Emphasize the slow onset of action to patients to ensure compliance.
- Monitor for diarrhea, especially in the initial weeks, and advise appropriate management.
- Consider liver function tests periodically, particularly if risk factors for hepatic impairment are present.
Patient Guidelines
- Take as prescribed, with food, to improve tolerability.
- Report any severe or persistent diarrhea to your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Be aware that the onset of action is slow; continue treatment even if immediate improvement is not seen.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
Movigel is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a healthy weight to reduce stress on joints.
- Engage in low-impact exercises like walking or swimming to improve joint mobility.
- Consider physiotherapy to strengthen muscles around affected joints.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Movigel Brand
Other medicines available under the same brand name
