Msl-Retard
Generic Name
Meloxicam
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| msl retard 15 mg tablet | ৳ 14.00 | ৳ 140.00 |
Description
Overview of the medicine
Msl-Retard 15 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness caused by arthritis. It works by blocking certain natural substances in the body that cause inflammation.
Uses & Indications
Dosage
Adults
15 mg once daily, preferably with food. Maximum recommended daily dose is 15 mg.
Elderly
Initially 7.5 mg once daily, may be increased to 15 mg once daily if needed and tolerated.
Renal_impairment
Severe renal impairment (CrCl < 30 mL/min): Contraindicated. Moderate impairment: Dose reduction may be required, monitor closely.
How to Take
Take orally once daily with water, with or after food. Do not crush, chew, or break the extended-release tablet.
Mechanism of Action
Meloxicam selectively inhibits cyclooxygenase-2 (COX-2) enzyme, which is responsible for the synthesis of prostaglandins, inflammatory mediators. By inhibiting COX-2, it reduces pain, inflammation, and fever.
Pharmacokinetics
Onset
Pain relief usually starts within 30-60 minutes, but full effect for chronic conditions may take longer.
Excretion
Approximately 50% excreted in urine and 50% in feces, primarily as inactive metabolites.
Half life
Approximately 15-20 hours.
Absorption
Well absorbed from the gastrointestinal tract, bioavailability about 89%. Food has no effect on absorption.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9 and to a lesser extent CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Meloxicam or other NSAIDs
- Active gastrointestinal bleeding or peptic ulceration
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels.
Diuretics
Decreased diuretic effect.
Methotrexate
Increased methotrexate toxicity.
Warfarin, Heparin
Increased risk of bleeding.
ACE inhibitors, Angiotensin II Receptor Blockers
Decreased antihypertensive effect, increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care, gastric decontamination (e.g., activated charcoal) if recent ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimester), Category D (third trimester). Avoid in the third trimester due to risk of premature closure of fetal ductus arteriosus. Use only if potential benefit outweighs risk during first and second trimesters. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Meloxicam or other NSAIDs
- Active gastrointestinal bleeding or peptic ulceration
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- Coronary Artery Bypass Graft (CABG) surgery (peri-operative pain)
Drug Interactions
Lithium
Increased plasma lithium levels.
Diuretics
Decreased diuretic effect.
Methotrexate
Increased methotrexate toxicity.
Warfarin, Heparin
Increased risk of bleeding.
ACE inhibitors, Angiotensin II Receptor Blockers
Decreased antihypertensive effect, increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves symptomatic and supportive care, gastric decontamination (e.g., activated charcoal) if recent ingestion.
Pregnancy & Lactation
Pregnancy Category C (first and second trimester), Category D (third trimester). Avoid in the third trimester due to risk of premature closure of fetal ductus arteriosus. Use only if potential benefit outweighs risk during first and second trimesters. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for its efficacy and safety in various inflammatory conditions, demonstrating comparable efficacy to other NSAIDs with a potentially improved GI tolerability profile due to COX-2 selectivity.
Lab Monitoring
- Complete Blood Count (CBC)
- Liver Function Tests (LFTs)
- Renal Function Tests (RFTs)
- Blood pressure monitoring
Doctor Notes
- Consider gastroprotective agents for high-risk patients.
- Monitor renal function, blood pressure, and liver enzymes during prolonged therapy.
- Use the lowest effective dose for the shortest possible duration.
Patient Guidelines
- Take as directed by your doctor. Do not exceed the prescribed dose.
- Swallow the tablet whole; do not chew or crush.
- Inform your doctor about all other medications you are taking.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools) immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid smoking and excessive alcohol consumption.
- Engage in regular, low-impact exercise suitable for your condition.
- Maintain a balanced diet.
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