Multicod
Generic Name
Dextromethorphan HBr + Phenylephrine HCl + Chlorpheniramine Maleate (Combination Cough & Cold Preparation)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| multicod syrup | ৳ 100.00 | N/A |
Description
Overview of the medicine
Multicod is a combination medication typically containing a cough suppressant (Dextromethorphan), a decongestant (Phenylephrine), and an antihistamine (Chlorpheniramine Maleate). It is used to relieve symptoms of cough, common cold, flu, and allergies such as sneezing, runny nose, watery eyes, and nasal congestion.
Uses & Indications
Dosage
Adults
10 ml (2 teaspoonfuls) every 6 hours, not to exceed 4 doses in 24 hours.
Elderly
Use with caution; consider lower doses due to potential increased sensitivity and co-morbidities.
Renal_impairment
Use with caution; dose adjustment may be necessary for severe impairment.
How to Take
Oral. Take with or without food. Use measuring spoon/cup provided.
Mechanism of Action
Dextromethorphan acts centrally on the cough center in the medulla to suppress cough. Phenylephrine is a direct-acting sympathomimetic amine that acts as a vasoconstrictor, reducing nasal congestion. Chlorpheniramine Maleate is an alkylamine antihistamine that blocks H1 receptors, reducing sneezing, runny nose, and watery eyes.
Pharmacokinetics
Onset
Dextromethorphan: 15-30 minutes; Phenylephrine: 15-30 minutes; Chlorpheniramine: 30-60 minutes
Excretion
Primarily excreted in urine as metabolites and some unchanged drug.
Half life
Dextromethorphan: 1.4-3.9 hours; Phenylephrine: 2-3 hours; Chlorpheniramine: 12-43 hours
Absorption
Dextromethorphan, Phenylephrine, and Chlorpheniramine are well absorbed orally. Dextromethorphan undergoes rapid and extensive hepatic first-pass metabolism.
Metabolism
Dextromethorphan is extensively metabolized in the liver by CYP2D6. Phenylephrine is metabolized in the liver and intestine. Chlorpheniramine is extensively metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to any component
- Concurrent use with MAO inhibitors or within 14 days of stopping MAO inhibitors
- Severe hypertension, severe coronary artery disease
- Narrow-angle glaucoma
Drug Interactions
MAO Inhibitors
May cause hypertensive crisis and increased CNS depression.
Antihypertensive drugs
Reduced hypotensive effects of antihypertensives (due to phenylephrine).
Tricyclic antidepressants
Potentiated effects of phenylephrine.
Other CNS depressants (alcohol, sedatives)
Increased sedation.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dizziness, nausea, vomiting, rapid heart rate, hypertension, hallucinations, seizures. Management involves symptomatic and supportive measures.
Pregnancy & Lactation
Consult a doctor before use during pregnancy or lactation. Generally not recommended unless clearly necessary, due to potential risks from individual components.
Side Effects
Contraindications
- Hypersensitivity to any component
- Concurrent use with MAO inhibitors or within 14 days of stopping MAO inhibitors
- Severe hypertension, severe coronary artery disease
- Narrow-angle glaucoma
Drug Interactions
MAO Inhibitors
May cause hypertensive crisis and increased CNS depression.
Antihypertensive drugs
Reduced hypotensive effects of antihypertensives (due to phenylephrine).
Tricyclic antidepressants
Potentiated effects of phenylephrine.
Other CNS depressants (alcohol, sedatives)
Increased sedation.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, dizziness, nausea, vomiting, rapid heart rate, hypertension, hallucinations, seizures. Management involves symptomatic and supportive measures.
Pregnancy & Lactation
Consult a doctor before use during pregnancy or lactation. Generally not recommended unless clearly necessary, due to potential risks from individual components.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies and drug stores nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available, likely off-patent
Clinical Trials
Standard combination has been subject to numerous clinical studies for efficacy and safety.
Lab Monitoring
- No routine lab monitoring required for typical use.
- Monitor blood pressure in patients with hypertension.
Doctor Notes
- Advise patients on potential for drowsiness and avoidance of activities requiring alertness.
- Counsel on avoiding concomitant use of other cough/cold products.
- Monitor for cardiovascular effects in patients with pre-existing conditions.
Patient Guidelines
- Do not exceed recommended dose.
- Avoid driving or operating machinery if experiencing drowsiness.
- Consult a doctor if symptoms persist for more than 7 days or worsen.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose.
Driving Precautions
May cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Get adequate rest.
- Stay hydrated.
- Avoid irritants like smoke or dust.
- Humidifiers may help with congestion.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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