Mupitas
Generic Name
Mupirocin 2% w/w Ointment
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mupitas 2 w ointment | ৳ 140.00 | N/A |
Description
Overview of the medicine
Mupirocin 2% w/w Ointment is a topical antibiotic used to treat bacterial skin infections such as impetigo and other skin lesions caused by susceptible bacteria.
Uses & Indications
Dosage
Adults
Apply a small amount of the ointment to the affected area 2 to 3 times daily for 5 to 10 days. Cover the treated area with gauze if desired.
Elderly
No dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is generally required as systemic absorption is minimal.
How to Take
For external use only. Wash hands before and after applying the ointment. Apply a thin layer to the affected skin area.
Mechanism of Action
Mupirocin inhibits bacterial protein synthesis by reversibly binding to bacterial isoleucyl-tRNA synthetase, thus preventing the incorporation of isoleucine into bacterial proteins.
Pharmacokinetics
Onset
Typically, improvement is seen within 3-5 days of treatment.
Excretion
The inactive metabolite is primarily excreted via the kidneys.
Half life
Plasma half-life of systemically absorbed mupirocin is 20-40 minutes.
Absorption
Systemic absorption of mupirocin through intact skin is minimal. Increased absorption may occur through abraded skin.
Metabolism
Any systemically absorbed mupirocin is rapidly metabolized to an inactive metabolite (monic acid) in the skin and liver.
Side Effects
Contraindications
- Hypersensitivity to mupirocin or any of the excipients of the ointment.
- Not for ophthalmic or intranasal use (unless specified as nasal ointment).
Drug Interactions
Chloramphenicol
Mupirocin should not be co-administered with other topical products as this may result in dilution of the Mupirocin and a potential reduction in activity. Specifically, chloramphenicol may antagonize the action of mupirocin.
Storage
Store below 25°C to 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause systemic toxicity due to minimal absorption. In case of accidental ingestion, provide symptomatic and supportive treatment.
Pregnancy & Lactation
Pregnancy Category B. Mupirocin should be used during pregnancy only if clearly needed. Caution should be exercised when mupirocin is administered to a nursing mother, as it is not known whether mupirocin is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to mupirocin or any of the excipients of the ointment.
- Not for ophthalmic or intranasal use (unless specified as nasal ointment).
Drug Interactions
Chloramphenicol
Mupirocin should not be co-administered with other topical products as this may result in dilution of the Mupirocin and a potential reduction in activity. Specifically, chloramphenicol may antagonize the action of mupirocin.
Storage
Store below 25°C to 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Topical overdose is unlikely to cause systemic toxicity due to minimal absorption. In case of accidental ingestion, provide symptomatic and supportive treatment.
Pregnancy & Lactation
Pregnancy Category B. Mupirocin should be used during pregnancy only if clearly needed. Caution should be exercised when mupirocin is administered to a nursing mother, as it is not known whether mupirocin is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of mupirocin in treating various bacterial skin infections compared to placebo and other topical antibiotics.
Lab Monitoring
- No specific laboratory monitoring is typically required for topical mupirocin.
Doctor Notes
- Emphasize the importance of completing the full course of treatment to prevent resistance.
- Advise patients on proper application technique and hygiene.
- Counsel patients to report any signs of irritation or worsening condition.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
- Avoid contact with eyes. If contact occurs, rinse thoroughly with water.
- Do not use for more than 10 days unless directed by your doctor.
- Discontinue use and consult your doctor if irritation or sensitivity occurs.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra ointment to make up for a missed dose.
Driving Precautions
Mupirocin ointment is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good personal hygiene to prevent the spread of infection.
- Avoid sharing towels or personal items with others.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.