my-jelly
Generic Name
Sildenafil Citrate
Manufacturer
MediGen Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
my jelly 1125 gel | ৳ 55.00 | N/A |
Description
Overview of the medicine
My-jelly 1125 Gel is an oral jelly formulation containing Sildenafil Citrate 100 mg, used for the treatment of erectile dysfunction. It provides a convenient and fast-acting alternative to traditional tablets, designed for ease of administration.
Uses & Indications
Dosage
Adults
The recommended initial dose is 50 mg taken approximately 1 hour before sexual activity. The dose may be increased to 100 mg or decreased to 25 mg based on efficacy and tolerability. My-jelly 1125 Gel (100 mg) may be suitable for patients requiring the maximum dose or as prescribed by a physician.
Elderly
Dosage adjustment is generally not required for elderly patients. However, due to potential increased sensitivity, a starting dose of 25 mg should be considered.
Renal_impairment
For patients with severe renal impairment (creatinine clearance < 30 mL/min), a starting dose of 25 mg should be considered.
How to Take
Tear the sachet and squeeze the entire contents directly into the mouth. It can be taken with or without food, but a high-fat meal may delay the onset of action. Do not exceed one dose per day.
Mechanism of Action
Sildenafil works by inhibiting phosphodiesterase type 5 (PDE5), an enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. This leads to increased cGMP levels, resulting in smooth muscle relaxation and increased blood flow into the penis, facilitating an erection upon sexual stimulation.
Pharmacokinetics
Onset
Typically within 30-60 minutes.
Excretion
Excreted predominantly as metabolites in the feces (approximately 80% of administered oral dose) and, to a lesser extent, in the urine (approximately 13% of administered oral dose).
Half life
Approximately 3-5 hours.
Absorption
Rapidly absorbed, with peak plasma concentrations reached within 30-120 minutes (median 60 minutes) after oral administration. Bioavailability is approximately 41%.
Metabolism
Primarily metabolized by CYP3A4 (major route) and CYP2C9 (minor route) in the liver, with the main active metabolite, N-desmethyl sildenafil.
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin) in any form, as it may potentiate hypotensive effects.
- Hypersensitivity to Sildenafil or any component of the formulation.
- Severe cardiovascular disease, recent myocardial infarction or stroke.
- Uncontrolled hypertension or hypotension.
Drug Interactions
Nitrates
Potentiation of hypotensive effects, potentially life-threatening. Concomitant use is contraindicated.
Alpha-blockers
May lead to symptomatic hypotension, especially with concomitant use. Initiate Sildenafil at lower doses and ensure patients are stable on alpha-blocker therapy.
CYP3A4 Inhibitors
Strong inhibitors (e.g., ketoconazole, ritonavir) may significantly increase Sildenafil exposure, requiring dose reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In volunteers, single doses up to 800 mg have shown similar adverse effects to lower doses, but with increased incidence and severity. In cases of overdose, standard supportive measures should be adopted as clinically indicated.
Pregnancy & Lactation
My-jelly 1125 Gel is not indicated for use in women. Safety in pregnancy and lactation has not been established for ED indications.
Side Effects
Contraindications
- Concomitant use with nitrates (e.g., nitroglycerin) in any form, as it may potentiate hypotensive effects.
- Hypersensitivity to Sildenafil or any component of the formulation.
- Severe cardiovascular disease, recent myocardial infarction or stroke.
- Uncontrolled hypertension or hypotension.
Drug Interactions
Nitrates
Potentiation of hypotensive effects, potentially life-threatening. Concomitant use is contraindicated.
Alpha-blockers
May lead to symptomatic hypotension, especially with concomitant use. Initiate Sildenafil at lower doses and ensure patients are stable on alpha-blocker therapy.
CYP3A4 Inhibitors
Strong inhibitors (e.g., ketoconazole, ritonavir) may significantly increase Sildenafil exposure, requiring dose reduction.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In volunteers, single doses up to 800 mg have shown similar adverse effects to lower doses, but with increased incidence and severity. In cases of overdose, standard supportive measures should be adopted as clinically indicated.
Pregnancy & Lactation
My-jelly 1125 Gel is not indicated for use in women. Safety in pregnancy and lactation has not been established for ED indications.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
Clinical Trials
Numerous clinical trials have established the efficacy and safety of Sildenafil for erectile dysfunction, demonstrating significant improvement in erectile function compared to placebo. Studies specific to oral jelly formulations show comparable bioavailability and onset of action to conventional tablets, with potential for faster absorption.
Lab Monitoring
- No specific laboratory monitoring is typically required. However, routine monitoring for cardiovascular health may be advised for patients with pre-existing conditions.
Doctor Notes
- Emphasize the importance of sexual stimulation for efficacy.
- Advise patients on nitrate contraindication and potential interactions with alpha-blockers and CYP3A4 inhibitors.
- Educate on priapism and non-arteritic anterior ischemic optic neuropathy (NAION) as rare but serious adverse events.
Patient Guidelines
- Take My-jelly 1125 Gel approximately 1 hour before sexual activity.
- Do not take more than one dose in a 24-hour period.
- Avoid consuming large amounts of alcohol, as it can worsen erectile dysfunction and increase side effects.
- Seek immediate medical attention if you experience an erection lasting longer than 4 hours (priapism).
- Inform your doctor about all other medications you are taking, especially nitrates.
Missed Dose Advice
This medicine is taken as needed, not on a regular schedule. Therefore, a missed dose is not applicable.
Driving Precautions
My-jelly 1125 Gel may cause dizziness and visual disturbances. Patients should be aware of how they react to the medication before driving or operating machinery.
Lifestyle Advice
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
- Manage stress and anxiety, as these can impact erectile function.
- Consider quitting smoking, which can contribute to ED.
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