Mydlam
Generic Name
Mydlamol
Manufacturer
Meditop Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mydlam 75 mg tablet | ৳ 9.60 | ৳ 96.00 |
Description
Overview of the medicine
Mydlamol 75 mg Tablet is a non-opioid analgesic and antipyretic used for the symptomatic relief of mild to moderate pain and fever.
Uses & Indications
Dosage
Adults
75 mg orally every 6-8 hours as needed. Maximum daily dose should not exceed 300 mg.
Elderly
Lower doses may be required, and renal function should be monitored. Consult physician.
Renal_impairment
Dose adjustment needed; consult physician. Avoid in severe renal impairment.
How to Take
Take orally with a full glass of water, preferably after food or milk to minimize gastrointestinal upset. Do not crush, chew, or break the tablet.
Mechanism of Action
Mydlamol works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2, which are responsible for the synthesis of prostaglandins, mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Excreted mainly via urine as metabolites (approx. 70%) and a small portion in feces.
Half life
Approximately 2-4 hours
Absorption
Rapidly absorbed from the gastrointestinal tract, peak plasma concentrations reached within 1-2 hours after oral administration.
Metabolism
Primarily metabolized in the liver via glucuronidation and hydroxylation, forming inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Mydlamol or other NSAIDs (e.g., aspirin, ibuprofen)
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
Drug Interactions
Lithium
Mydlamol may increase plasma lithium levels, leading to toxicity.
Diuretics and ACE inhibitors
Reduced diuretic and antihypertensive effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs or corticosteroids
Increased risk of gastrointestinal side effects including ulcers and bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach and sight of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, dizziness, headache, and gastrointestinal bleeding. In severe cases, acute renal failure, hepatic dysfunction, hypotension, respiratory depression, and coma may occur. Management involves symptomatic and supportive care. Gastric lavage or activated charcoal may be considered within 1 hour of ingestion in significant overdose.
Pregnancy & Lactation
Avoid Mydlamol during the third trimester of pregnancy due to potential risks to the fetus, particularly premature closure of the ductus arteriosus. Use with caution during the first and second trimesters and during lactation, only if clearly needed and under strict medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired; Generic available
Clinical Trials
Clinical trials for Mydlamol 75 mg Tablet have demonstrated significant efficacy in pain and fever reduction compared to placebo, with a safety profile comparable to other non-selective NSAIDs. Further studies are ongoing to evaluate its long-term cardiovascular and gastrointestinal safety.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) periodically, especially with long-term use or in elderly patients.
- Liver function tests (e.g., ALT, AST) if signs of hepatic dysfunction appear.
- Complete blood count (CBC) for long-term use to monitor for anemia or other blood dyscrasias.
Doctor Notes
- Carefully assess patient's cardiovascular, gastrointestinal, and renal risk factors before initiating therapy.
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for signs and symptoms of GI bleeding or cardiovascular adverse events, especially in high-risk patients.
- Inform patients about the potential risks and symptoms requiring immediate medical attention.
Patient Guidelines
- Always follow your doctor's instructions and do not exceed the recommended dose.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools, vomiting blood) or severe allergic reactions immediately.
- Avoid self-medication with other NSAIDs while taking Mydlamol.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to compensate.
Driving Precautions
Mydlamol may cause dizziness or drowsiness in some individuals. Patients should exercise caution when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Avoid alcohol consumption while taking this medicine as it may increase the risk of gastrointestinal side effects.
- Maintain adequate hydration to support renal function.
- If experiencing dizziness, avoid activities requiring mental alertness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.