Mylomid
Generic Name
Lenalidomide
Manufacturer
Beacon Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mylomid 10 mg capsule | ৳ 200.00 | ৳ 1,400.00 |
Description
Overview of the medicine
Mylomid 10 mg Capsule contains Lenalidomide, an immunomodulatory and antineoplastic agent used in the treatment of various hematologic malignancies, including multiple myeloma and myelodysplastic syndromes.
Uses & Indications
Dosage
Adults
Dosage varies significantly based on the indication and patient's medical condition. For Multiple Myeloma, typically 25 mg orally once daily for 21 days of a 28-day cycle, in combination with dexamethasone. For MDS 5q deletion, typically 10 mg orally once daily. Always consult physician.
Elderly
Dosage adjustments may be necessary based on renal function and tolerability, similar to younger adults.
Renal_impairment
Significant dosage reduction required based on creatinine clearance (e.g., CrCl 30-60 mL/min: 10 mg daily or every other day; CrCl <30 mL/min: 5 mg daily or every other day).
How to Take
Take orally with or without food, at the same time each day. Swallow the capsule whole with water. Do not open, break, or chew the capsule. Handle with care, especially by pregnant individuals, due to teratogenicity.
Mechanism of Action
Lenalidomide exerts its effects through multiple mechanisms, including direct anti-tumor activity (inhibiting proliferation and inducing apoptosis), immunomodulatory effects (enhancing T-cell and NK-cell mediated immunity, inhibiting pro-inflammatory cytokines), and anti-angiogenic properties (inhibiting tumor neovascularization).
Pharmacokinetics
Onset
Not directly applicable as it's a chronic treatment, but immunomodulatory effects can start within days to weeks.
Excretion
Primarily excreted renally, with approximately 66% found in urine as unchanged drug.
Half life
Approximately 3-5 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations typically reached within 0.5-6 hours.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Pregnancy (Category X due to severe teratogenicity)
- Breastfeeding
- Hypersensitivity to lenalidomide or any excipients
Drug Interactions
Digoxin
Lenalidomide may increase Digoxin levels, monitor closely.
Dexamethasone
Enhances efficacy in multiple myeloma, but also increases risk of thromboembolism.
Erythropoietic stimulating agents (ESAs)
Increased risk of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, no specific antidote is available. Management should consist of supportive care, including monitoring for adverse effects, especially hematologic and thromboembolic events, and managing symptoms as they arise.
Pregnancy & Lactation
Category X. Absolutely contraindicated in pregnancy due to severe teratogenicity. Women of childbearing potential must use two reliable methods of contraception starting at least 4 weeks prior to therapy, during therapy, and for 4 weeks after therapy. Breastfeeding is also contraindicated.
Side Effects
Contraindications
- Pregnancy (Category X due to severe teratogenicity)
- Breastfeeding
- Hypersensitivity to lenalidomide or any excipients
Drug Interactions
Digoxin
Lenalidomide may increase Digoxin levels, monitor closely.
Dexamethasone
Enhances efficacy in multiple myeloma, but also increases risk of thromboembolism.
Erythropoietic stimulating agents (ESAs)
Increased risk of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, no specific antidote is available. Management should consist of supportive care, including monitoring for adverse effects, especially hematologic and thromboembolic events, and managing symptoms as they arise.
Pregnancy & Lactation
Category X. Absolutely contraindicated in pregnancy due to severe teratogenicity. Women of childbearing potential must use two reliable methods of contraception starting at least 4 weeks prior to therapy, during therapy, and for 4 weeks after therapy. Breastfeeding is also contraindicated.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies, specialized oncology centers
Approval Status
Approved by regulatory authorities (e.g., FDA, EMA, DGDA)
Patent Status
Original patent expired for Lenalidomide; generic versions available.
Clinical Trials
Lenalidomide has undergone extensive clinical trials supporting its efficacy and safety in multiple myeloma, MDS, and lymphoma, including studies like MM-002, MM-003, MDS-004, and MCL-002.
Lab Monitoring
- Complete blood count (CBC) with differential (weekly for first 8 weeks, then monthly)
- Liver function tests (LFTs)
- Renal function tests (RFTs)
- Thyroid function tests (periodically)
Doctor Notes
- Emphasize strict adherence to REMS/risk management program requirements.
- Educate patients on symptoms of thromboembolism and myelosuppression.
- Regular monitoring of CBC is critical, especially during initial cycles.
Patient Guidelines
- Strict adherence to the prescribed dosage and schedule.
- Do not donate blood or sperm during treatment and for 4 weeks after.
- Pregnant women should not handle this medication.
- Report any signs of blood clots, infection, or unusual bleeding immediately.
- Participate in mandatory risk management programs (e.g., RevAssist in some regions).
Missed Dose Advice
If a dose is missed by less than 12 hours, take it as soon as you remember. If more than 12 hours have passed, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.
Driving Precautions
Lenalidomide may cause fatigue, dizziness, or confusion. Patients should be advised to use caution when driving or operating machinery until they are reasonably certain that lenalidomide does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Maintain good hydration to reduce risk of DVT.
- Avoid activities that may increase risk of injury or bleeding due to potential thrombocytopenia.
- Consult doctor before using any new medication, including OTC drugs and herbal supplements.
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