Myrox-SR
Generic Name
Aceclofenac (Sustained Release)
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| myrox sr 75 mg capsule | ৳ 5.04 | ৳ 50.40 |
Description
Overview of the medicine
Myrox-SR 75 mg capsule contains Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation. The sustained-release formulation ensures prolonged action, making it suitable for chronic conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Uses & Indications
Dosage
Adults
The usual recommended dose is 75 mg once or twice daily, or 150 mg once daily, as directed by a physician. Maximum recommended daily dose is 150 mg.
Elderly
No dosage adjustment is usually required, but caution is advised due to increased risk of adverse effects. Consider the lowest effective dose.
Renal_impairment
No specific dose reduction for mild renal impairment, but caution is advised. Avoid in severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
Myrox-SR 75 mg capsules should be swallowed whole with water, preferably with or after food, to minimize gastrointestinal discomfort. Do not chew, crush, or break the capsule.
Mechanism of Action
Aceclofenac exerts its anti-inflammatory and analgesic effects by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are responsible for the synthesis of prostaglandins. Prostaglandins are key mediators of inflammation, pain, and fever.
Pharmacokinetics
Onset
Symptomatic relief usually begins within 1-2 hours for immediate release; sustained release formulations have a more gradual onset and prolonged effect.
Excretion
Approximately two-thirds of the dose is excreted in the urine, and one-third in the faeces, mainly as hydroxylated metabolites.
Half life
The plasma elimination half-life is approximately 4-4.3 hours. However, the sustained-release formulation allows for once-daily dosing due to extended release.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. Sustained-release formulation provides prolonged absorption. Peak plasma concentrations are typically reached within 1.25 to 3 hours for immediate release, with a more gradual profile for SR.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 enzymes (CYP2C9), to form 4'-hydroxyaceclofenac as the main metabolite, along with other inactive or less active metabolites.
Side Effects
Contraindications
- •Hypersensitivity to aceclofenac, aspirin, or other NSAIDs
- •History of active gastrointestinal ulceration, bleeding, or perforation
- •Severe heart failure, renal impairment, or hepatic impairment
- •Third trimester of pregnancy
- •Patients in whom aspirin or other NSAIDs precipitate attacks of asthma, urticaria, or acute rhinitis
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Decreased renal excretion of lithium, leading to increased plasma lithium levels and potential toxicity.
Methotrexate
Reduced tubular secretion of methotrexate, resulting in increased plasma concentrations and toxicity.
Corticosteroids
Increased risk of gastrointestinal ulceration or bleeding.
Diuretics and ACE inhibitors
Reduced natriuretic and antihypertensive effects, increased risk of renal impairment, especially in dehydrated patients.
Warfarin and other anticoagulants
Increased risk of bleeding due to synergistic antiplatelet effect and GI irritation.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of aceclofenac overdose may include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, diarrhoea, disorientation, excitation, coma, drowsiness, dizziness, tinnitus, fainting, and occasionally convulsions. Management involves symptomatic and supportive measures. Gastric lavage and activated charcoal may be considered within one hour of ingestion.
Pregnancy & Lactation
Myrox-SR is contraindicated during the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus. Use in the first and second trimesters should only be considered if the potential benefit justifies the potential risk to the fetus. It is generally not recommended during breastfeeding as aceclofenac may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 24 to 36 months from the manufacturing date, depending on the specific product and manufacturer.
Availability
Pharmacies, hospitals
Approval Status
Approved by national regulatory bodies (e.g., DGDA in Bangladesh)
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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