Mytil
Generic Name
Cyproheptadine Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mytil 4 mg syrup | ৳ 38.00 | N/A |
Description
Overview of the medicine
Mytil 4 mg Syrup is an antihistamine primarily used to relieve symptoms of allergic conditions such as hay fever, conjunctivitis, and urticaria. It also possesses appetite-stimulating properties and is often prescribed for weight gain in children and adults who have poor appetite.
Uses & Indications
Dosage
Adults
Allergic conditions: 4 mg three times a day initially; range 4-20 mg/day. Appetite stimulation: 4 mg three times a day.
Elderly
Lower initial dose (e.g., 2 mg twice a day) due to increased sensitivity and risk of side effects, especially anticholinergic effects.
Renal_impairment
Use with caution; consider dose reduction as it is primarily excreted renally. Specific guidelines not well-established, but monitoring for adverse effects is crucial.
How to Take
Mytil 4 mg Syrup is for oral administration. It can be taken with or without food. Use a measuring spoon or cup for accurate dosing, especially for children.
Mechanism of Action
Cyproheptadine is a first-generation antihistamine with anticholinergic, antiserotonergic, and local anesthetic properties. It competitively blocks H1 histamine receptors, thereby reducing the effects of histamine in allergic reactions. Its appetite-stimulating effect is believed to be due to its antagonism of serotonin receptors (5-HT2A, 5-HT2C) in the hypothalamus.
Pharmacokinetics
Onset
Antihistaminic effects within 15-30 minutes; peak appetite stimulation may take several days.
Excretion
Excreted mainly in the urine (about 2-20% as unchanged drug) and feces.
Half life
Approximately 16 hours (range 10-19 hours).
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver, primarily via glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to Cyproheptadine or any component of the formulation.
- Newborn or premature infants.
- Nursing mothers.
- Patients with angle-closure glaucoma, urinary retention, prostatic hypertrophy, or stenosing peptic ulcer.
- Elderly or debilitated patients.
Drug Interactions
MAO Inhibitors
May prolong and intensify the anticholinergic effects of cyproheptadine.
CNS Depressants
Concurrent use may enhance the sedative effects (e.g., alcohol, sedatives, hypnotics, tranquilizers).
Anticholinergics
Concurrent use with other anticholinergic drugs may increase the risk of anticholinergic side effects.
Storage
Store at room temperature (below 30°C), protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, dizziness, ataxia, dry mouth, fixed dilated pupils, flushing, gastrointestinal symptoms, and in severe cases, central nervous system depression or excitation. Management involves symptomatic and supportive treatment, including gastric lavage, activated charcoal, and monitoring vital signs.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Contraindicated in nursing mothers as it may be excreted in breast milk and cause adverse effects in infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Cyproheptadine has been subject to various clinical trials establishing its efficacy and safety for allergic conditions and appetite stimulation. Refer to specific literature for detailed trial information.
Lab Monitoring
- No specific routine lab tests are typically required.
- Monitor complete blood count periodically if long-term therapy is given, especially if blood dyscrasias are suspected.
Doctor Notes
- Advise patients about potential drowsiness and to avoid activities requiring mental alertness.
- Monitor weight and growth in children receiving this for appetite stimulation.
- Caution in patients with a history of asthma, narrow-angle glaucoma, or urinary retention.
Patient Guidelines
- May cause drowsiness; avoid driving or operating machinery until you know how it affects you.
- Avoid alcohol and other CNS depressants.
- Take with food or milk if stomach upset occurs.
- Do not stop taking the medicine suddenly without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Use with caution. May cause drowsiness or dizziness, which can impair ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet and regular mealtimes to support appetite stimulation.
- Stay hydrated by drinking plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.