Nabulex
Generic Name
nabulex-20-mg-injection
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nabulex 20 mg injection | ৳ 100.30 | N/A |
Description
Overview of the medicine
Nabulex 20 mg Injection is a potent non-steroidal anti-inflammatory drug (NSAID) primarily used for the rapid relief of moderate to severe pain and inflammation. It is administered parenterally for quick onset of action.
Uses & Indications
Dosage
Adults
For acute pain, 20 mg IM or IV every 6-8 hours as needed. Maximum dose 60 mg/day for a short duration (e.g., 2-3 days).
Elderly
Lower doses may be required (e.g., 10 mg every 8-12 hours) due to increased risk of adverse effects; close monitoring is recommended.
Renal_impairment
Use with caution. Dosage reduction to 10 mg daily or less frequent administration may be necessary for moderate impairment. Contraindicated in severe renal impairment.
How to Take
For intramuscular (IM) injection, administer slowly into a large muscle. For intravenous (IV) injection, Nabulex 20 mg should be diluted in 50-100 mL of 0.9% normal saline or 5% dextrose solution and infused over 15-30 minutes.
Mechanism of Action
Nabulex exerts its analgesic and anti-inflammatory effects by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever. Its parenteral form ensures faster bioavailability.
Pharmacokinetics
Onset
10-20 minutes (intravenous); 20-40 minutes (intramuscular)
Excretion
Excreted predominantly in urine as metabolites, with some fecal excretion.
Half life
Approximately 4-6 hours
Absorption
Rapid and complete absorption following intramuscular or intravenous administration. Peak plasma concentrations achieved within 15-30 minutes.
Metabolism
Primarily hepatic metabolism, extensive first-pass metabolism.
Side Effects
Contraindications
- Hypersensitivity to Nabulex or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Patients undergoing coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Diuretics and ACE Inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive care, gastric lavage (if recent oral ingestion, though not applicable for injection), activated charcoal (if recent oral ingestion), and symptomatic treatment. Hemodialysis is unlikely to be beneficial.
Pregnancy & Lactation
Use should be avoided in the third trimester of pregnancy due to potential risks to the fetus. In early pregnancy and during lactation, use only if clearly necessary and potential benefits outweigh risks. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Nabulex or other NSAIDs
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- Patients undergoing coronary artery bypass graft (CABG) surgery
Drug Interactions
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased plasma methotrexate levels, leading to toxicity.
Diuretics and ACE Inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Management involves supportive care, gastric lavage (if recent oral ingestion, though not applicable for injection), activated charcoal (if recent oral ingestion), and symptomatic treatment. Hemodialysis is unlikely to be beneficial.
Pregnancy & Lactation
Use should be avoided in the third trimester of pregnancy due to potential risks to the fetus. In early pregnancy and during lactation, use only if clearly necessary and potential benefits outweigh risks. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Hospitals, Clinics, Pharmacies (with prescription)
Approval Status
Approved by DGDA (hypothetical)
Patent Status
Patent Pending
Clinical Trials
Clinical trials demonstrated significant efficacy in reducing acute pain compared to placebo, with a favorable safety profile for short-term use. Studies are ongoing to evaluate long-term safety and efficacy.
Lab Monitoring
- Regular monitoring of renal function (creatinine, BUN)
- Liver function tests (ALT, AST)
- Complete blood count (CBC) with differential, especially for long-term use
- Blood pressure monitoring
Doctor Notes
- Assess renal and cardiovascular risk factors before prescribing.
- Use the lowest effective dose for the shortest duration necessary.
- Consider gastroprotective agents for high-risk patients.
- Educate patients on symptoms of GI bleeding and cardiac events.
Patient Guidelines
- Inform your doctor about all existing medical conditions and other medications.
- Do not exceed the prescribed dose or duration of treatment.
- Report any unusual bleeding, persistent stomach pain, or severe allergic reactions immediately.
- Avoid alcohol consumption during treatment.
- The injection will be administered by a healthcare professional.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
Nabulex 20 mg Injection may cause dizziness or drowsiness. Patients should be advised to avoid driving or operating machinery if they experience these side effects.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid activities that require alertness if dizziness occurs.
- Follow a balanced diet.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.