Naburel
Generic Name
Nabumetone
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| naburel 500 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Nabumetone is a non-acidic non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation associated with various conditions such as osteoarthritis and rheumatoid arthritis. It is a prodrug that gets converted to its active metabolite in the body.
Uses & Indications
Dosage
Adults
The usual initial dose is 1000 mg once daily, taken as two 500 mg tablets. Some patients may require 1500-2000 mg daily. Max 2000 mg/day.
Elderly
Start with lower doses and monitor for adverse effects, especially renal and GI. Usually 500-1000 mg once daily.
Renal_impairment
Use with caution. Dosage reduction may be necessary in patients with severe renal impairment (CrCl < 30 mL/min).
How to Take
Take orally, preferably with food or milk to reduce gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Nabumetone is a prodrug that is converted to its active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA). 6-MNA inhibits prostaglandin synthesis by inhibiting cyclooxygenase (COX) enzymes, with a preferential inhibition of COX-2, leading to anti-inflammatory, analgesic, and antipyretic effects.
Pharmacokinetics
Onset
Pain relief may begin within 1-2 hours; full anti-inflammatory effects may take longer (days to weeks).
Excretion
Primarily excreted in the urine (approximately 75% as metabolites) and a smaller amount in feces.
Half life
The active metabolite (6-MNA) has a plasma half-life of approximately 20-24 hours.
Absorption
Well absorbed from the gastrointestinal tract. Food can increase absorption.
Metabolism
Extensively metabolized in the liver to its active metabolite (6-MNA) and other inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to nabumetone or any NSAID
- Patients with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal ulceration or bleeding
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors and diuretics
Reduced antihypertensive and diuretic effects, potential for renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs or corticosteroids
Increased risk of gastrointestinal side effects.
Antiplatelet agents (e.g., Aspirin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, and epigastric pain. Management is supportive and symptomatic; gastric lavage or activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus. Use with caution and only if clearly needed in early pregnancy and during lactation, as NSAIDs can pass into breast milk.
Side Effects
Contraindications
- Hypersensitivity to nabumetone or any NSAID
- Patients with a history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal ulceration or bleeding
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors and diuretics
Reduced antihypertensive and diuretic effects, potential for renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs or corticosteroids
Increased risk of gastrointestinal side effects.
Antiplatelet agents (e.g., Aspirin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include lethargy, drowsiness, nausea, vomiting, and epigastric pain. Management is supportive and symptomatic; gastric lavage or activated charcoal may be considered within the first hour of ingestion.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to the risk of premature closure of the fetal ductus arteriosus. Use with caution and only if clearly needed in early pregnancy and during lactation, as NSAIDs can pass into breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date, as indicated on the pack.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available, patent expired
Clinical Trials
Nabumetone has undergone extensive clinical trials demonstrating its efficacy and safety for its approved indications. Ongoing research may explore its role in other inflammatory conditions or optimize its use.
Lab Monitoring
- Monitor renal function (serum creatinine, BUN) periodically, especially in long-term therapy or in patients with pre-existing renal impairment.
- Monitor liver function tests (ALT, AST) periodically.
- Monitor complete blood count (CBC) for signs of anemia or other hematological abnormalities in long-term use.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
- Monitor for signs of GI bleeding, cardiovascular events, and renal toxicity.
- Educate patients on potential adverse effects and when to seek medical attention.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual symptoms or side effects to your doctor.
- Read the patient information leaflet carefully before starting the medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid or limit alcohol consumption during treatment.
- If gastrointestinal upset occurs, take the medicine with food or milk.
- Maintain adequate hydration.
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