Nafgal
Generic Name
Naphazoline Hydrochloride + Chlorpheniramine Maleate
Manufacturer
Aristopharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nafgal 2 cream | ৳ 80.00 | N/A |
Description
Overview of the medicine
Nafgal Eye Drop is a combination medication containing Naphazoline Hydrochloride, a sympathomimetic amine, and Chlorpheniramine Maleate, an antihistamine. It is used to relieve redness, itching, and congestion associated with allergic conjunctivitis and minor eye irritations.
Uses & Indications
Dosage
Adults
1-2 drops in the affected eye(s) up to 4 times a day, or as directed by physician. Do not use for more than 3-4 consecutive days.
Elderly
Same as adult dosage. Use with caution due to potential systemic effects in elderly.
Renal_impairment
No specific dose adjustment provided, but minimal systemic absorption suggests low risk.
How to Take
For ophthalmic use only. Tilt head back, pull down lower eyelid to create a pouch, and instill drops. Close eye gently for a few seconds. Do not touch the dropper tip to any surface.
Mechanism of Action
Naphazoline acts as a vasoconstrictor, reducing redness by constricting conjunctival blood vessels. Chlorpheniramine Maleate is an antihistamine that blocks H1 receptors, thereby reducing itching and allergic symptoms.
Pharmacokinetics
Onset
Rapid onset, typically within minutes
Excretion
Primarily through local metabolism and minimal systemic excretion via kidneys if absorbed
Half life
Not well characterized for ocular use due to minimal systemic absorption
Absorption
Minimal systemic absorption through ocular route
Metabolism
Likely metabolized by liver enzymes if absorbed systemically, but local metabolism is primary for Naphazoline
Side Effects
Contraindications
- Hypersensitivity to any component
- Narrow-angle glaucoma
- Use with MAO inhibitors
Drug Interactions
MAO Inhibitors
May cause hypertensive crisis if systemically absorbed
Tricyclic Antidepressants
Potentiate the pressor effect of sympathomimetic amines
Storage
Store in a cool, dry place, below 25°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Excessive use may lead to increased systemic absorption causing central nervous system depression, hypotension, and bradycardia. Symptomatic and supportive treatment.
Pregnancy & Lactation
Use with caution if potential benefits outweigh risks. Consult a doctor. Minimal systemic absorption but data are limited.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years unopened. Discard 28 days after opening.
Availability
Available in pharmacies across Bangladesh
Approval Status
Approved by DGDA
Patent Status
Generic, patent expired
Clinical Trials
Standard clinical trials established efficacy and safety for ocular decongestant and antihistamine use.
Lab Monitoring
- Not typically required for topical ocular use.
Doctor Notes
- Advise patients against prolonged use due to risk of rebound hyperemia.
- Caution in patients with cardiovascular disease, hypertension, hyperthyroidism, or diabetes due to systemic absorption potential of naphazoline.
- Evaluate for narrow-angle glaucoma before prescribing.
Patient Guidelines
- Do not use for more than 3-4 days without consulting a doctor.
- Remove contact lenses before use and wait at least 15 minutes before reinserting.
- Avoid touching the dropper tip to prevent contamination.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision or pupil dilation. Avoid driving or operating machinery until vision is clear.
Lifestyle Advice
- Avoid triggers that cause eye irritation or allergies.
- Maintain good eye hygiene.
- Wear sunglasses outdoors to protect eyes from irritants.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.